Structural and Evolutionary Genomics: Natural Selection in Genome EvolutionStructural genomics is the study of the DNA of living organisms. Evolutionary genomics is the study of the history of the genome. These subjects are closely interlinked. They are approached in this book using as a guideline the investigations carried out in the author's laboratory, relevant literature is critically reviewed and some general conclusions are presented. The author and his collaborators have studied a vast number of genomes, ranging from prokaryotes to human, using different approaches, including physical chemistry of DNA, viral integration and molecular cytogenetics. As the subtitle indicates the book discusses the fundamental importance of natural selection in shaping genomes. In terms of numbers, neutral and nearly neutral mutations represent most mutations, but a "regional" control is exerted by natural selection (essentially negative or purifying selection). A "neo-selectionist" model is proposed for genome evolution. · Summarizes the existing knowledge on genome organization and evolution in a self-contained book · Discusses important open problem, without refraining from criticism whenever appropriate |
Contents
| 19 | |
THE ORGANIZATION OF THE VERTEBRATE GENOME | 49 |
THE COMPOSITIONAL PATTERNS OF VERTEBRATE GENOMES | 81 |
SEQUENCE DISTRIBUTION IN THE VERTEBRATE GENOMES | 121 |
THE DISTRIBUTION OF INTEGRATED VIRAL SEQUENCES TRANSPOSONS AND DUPLICATED GENES IN THE MAMMALIAN GENOME | 147 |
THE ORGANIZATION OF CHROMOSOMES IN VERTEBRATES | 177 |
THE ORGANIZATION OF PLANT GENOMES | 217 |
THE COMPOSITIONAL PATTERNS OF THE GENOMES OF INVERTEBRATES UNICELLULAR EUKARYOTES AND PROKARYOTES | 241 |
THE COMPOSITIONAL EVOLUTION OF VERTEBRATE GENOMES | 293 |
NATURAL SELECTION AND GENETIC DRIFT IN GENOME EVOLUTION THE NEOSELECTIONIST MODEL | 325 |
RECAPITULATION | 369 |
CONCLUSIONS | 385 |
Abbreviations | 389 |
References | 391 |
| 435 | |
AN UPDATE | 440 |
Other editions - View all
Structural and Evolutionary Genomics: Natural Selection in Genome Evolution Giorgio Bernardi No preview available - 2005 |
Structural and Evolutionary Genomics: Natural Selection in Genome Evolution Giorgio Bernardi No preview available - 2005 |
Common terms and phrases
amino acids Arabidopsis base composition Bernardi and Bernardi Bernardi G Biol buoyant density cells chromatin chromosomal bands chromosome 21 coding sequences codon codon usage cold-blooded vertebrates compositional heterogeneity compositional patterns compositional transition compositionally correlation corresponding CpG islands CsCl CsCl profiles D'Onofrio density gradient DNA fractions DNA sequences Drosophila eukaryotic Evol evolution evolutionary Figure fishes frequency G bands g/cm³ GC content GC levels GC-rich isochores GC-richest gene density gene distribution gene space Genet genome core genome of yeast H3 isochores histogram human chromosomes human genome hybridization hydrophobicity indicated integration introns isochore families isochores Jabbari located maize major mammalian methylation mitochondrial genome modal buoyant densities molecular Mouchiroud mouse mutations neutral theory noncoding sequences nucleotide plot prokaryotes proteins recombination regions relative amounts replication reptiles Saccone satellite DNAs segments showed species structure temperature tion transcription transposons vertebrate genomes vertebrates warm-blooded warm-blooded vertebrates wild-type Xenopus Zamaroczy Zoubak