CN103977465B - A kind of implantating biological artificial kidney device - Google Patents
A kind of implantating biological artificial kidney device Download PDFInfo
- Publication number
- CN103977465B CN103977465B CN201410039297.2A CN201410039297A CN103977465B CN 103977465 B CN103977465 B CN 103977465B CN 201410039297 A CN201410039297 A CN 201410039297A CN 103977465 B CN103977465 B CN 103977465B
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- CN
- China
- Prior art keywords
- artificial kidney
- biological artificial
- implantating biological
- patient
- polyethylene glycol
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1678—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes intracorporal
Abstract
A kind of implantating biological artificial kidney device, it relates to field of medical article technology.The inside of implantating biological artificial kidney body (1) is provided with nanoscale polyethylene glycol silicon grain film (3), the arranged outside of nanoscale polyethylene glycol silicon grain film (3) has renal cells layer (2), one end of implantating biological artificial kidney body (1) is communicated with arterial end (4), the other end of implantating biological artificial kidney body (1) is connected with vein end (5), and one end of urine flow pass (6) is connected with implantating biological artificial kidney body (1).Its structure is simple, and volume is little, implantable in patient body, facilitates the treatment of dialysis patient, has widened the range of activity of patient.
Description
Technical field
The present invention relates to field of medical article technology, be specifically related to a kind of implantating biological artificial kidney device and application thereof.
Background technology
Along with the change that social development and people's lives are accustomed to, the incidence rate of hypertension and diabetes increases year by year.Thus, the most important common complication of these two kinds of diseases---the sickness rate of chronic renal failure also significantly rises.Patients of chronic renal failure finally all will enter into Uremic (hereinafter referred to as uremia).In the world following three kinds of modes are mainly contained to uremic treatment at present: renal transplantation, hemodialysis and peritoneal dialysis.Due to the shortage in kidney source in global range, cause can accepting kidney transfer operation less than the uremic patient of 1% at present.
Although hemodialysis and peritoneal dialysis can solve the viability problems of uremic patient, all limit its clinical practice due to himself Problems existing.Such as, hemodialysis patients needs ability completed treatment in hospital at present, limits the range of activity of patient and the problem of working.In addition, although peritoneal dialysis treatment can carry out at home patient, need when patient goes on a journey to carry a large amount of peritoneal dialysis solutions, very inconvenient.
Summary of the invention
The object of this invention is to provide a kind of implantating biological artificial kidney device, its structure is simple, and volume is little, implantable in patient body, facilitates the treatment of dialysis patient, has widened the range of activity of patient.
In order to solve the problem existing for background technology, the present invention is by the following technical solutions: it comprises implantating biological artificial kidney body 1, renal cells layer 2, nanoscale polyethylene glycol silicon grain film 3, arterial end 4, vein end 5 and urine flow pass 6, the inside of implantating biological artificial kidney body 1 is provided with nanoscale polyethylene glycol silicon grain film 3, the arranged outside of nanoscale polyethylene glycol silicon grain film 3 has renal cells layer 2, one end of implantating biological artificial kidney body 1 is communicated with arterial end 4, the other end of implantating biological artificial kidney body 1 is connected with vein end 5, and urine flow pass 6 one end is connected with implantating biological artificial kidney body 1.
Application process of the present invention is: its arterial end 4 is connected with renal artery, in the conduit reflux that the blood of uremic patient is connected with renal veins by vein end 5 through " cleaning " of this implantating biological artificial kidney body 1, blood in device in vivo under the effect of blood pressure power through the filtration of nanoscale polyethylene glycol silicon grain film 3, formed " crude urine ", nanoscale polyethylene glycol silicon grain film 3 is similar to mankind's glomerular filtration membrane, is greater than 4.2 ten thousand daltonian molecules plays good barrier effect for molecular weight.Compared with uremic patient body inner blood composition, in " crude urine ", substantially there is no macromolecular components such as immunoglobulin etc., during uremic toxins is also filtered across " crude urine ", but aminoacid, glucose, small molecular protein, electrolyte ingredient and the HCO in it
3 -deng similar with blood.The renal cells structure 2 of composition in " crude urine " in device heavily absorbs, the aminoacid in it, glucose, small molecular protein, electrolyte ingredient and HCO
3 -reuptaked into blood Deng again, be back in body.Residue metabolite, acid ingredient etc. in " crude urine " then flow to bladder with urine flow pass 6 and excrete.Human renal tubular epithelial cells has regeneration function, can constantly " supplement ", and " urine " that the renal cells of apoptosis itself and metabolite produce after then filtering with this device is excreted by urine flow pass 6.
The present invention has following beneficial effect: its structure is simple, and volume is little, implantable in patient body, facilitates the treatment of dialysis patient, has widened the range of activity of patient.
Accompanying drawing illustrates:
Fig. 1 is structural representation of the present invention.
Detailed description of the invention:
With reference to Fig. 1, this detailed description of the invention takes following technical scheme: it comprises implantating biological artificial kidney body 1, renal cells layer 2, nanoscale polyethylene glycol silicon grain film 3, arterial end 4, vein end 5 and urine flow pass 6, the inside of implantating biological artificial kidney body 1 is provided with nanoscale polyethylene glycol silicon grain film 3, the arranged outside of nanoscale polyethylene glycol silicon grain film 3 has renal cells layer 2, one end of implantating biological artificial kidney body 1 is communicated with arterial end 4, the other end of implantating biological artificial kidney body 1 is connected with vein end 5, and urine flow pass 6 one end is connected with implantating biological artificial kidney body 1.
The application process of this detailed description of the invention is: its arterial end 4 is connected with renal artery, in the conduit reflux that the blood of uremic patient is connected with renal veins by vein end 5 through " cleaning " of this implantating biological artificial kidney body 1, blood in device in vivo under the effect of blood pressure power through the filtration of nanoscale polyethylene glycol silicon grain film 3, formed " crude urine ", nanoscale polyethylene glycol silicon grain film 3 is similar to mankind's glomerular filtration membrane, 4.2 ten thousand daltonian molecules are greater than for molecular weight and play good barrier effect, compared with uremic patient body inner blood composition, substantially macromolecular components such as immunoglobulin etc. is not had in " crude urine ", during uremic toxins is also filtered across " crude urine ", but the aminoacid in it, glucose, small molecular protein, electrolyte ingredient and HCO
3 -deng similar with blood.The renal cells structure 2 of composition in " crude urine " in device heavily absorbs, the aminoacid in it, glucose, small molecular protein, electrolyte ingredient and HCO
3 -reuptaked into blood Deng again, be back in body.Residue metabolite, acid ingredient etc. in " crude urine " then flow to bladder with urine flow pass 6 and excrete.Human renal tubular epithelial cells has regeneration function, can constantly " supplement ", and " urine " that the renal cells of apoptosis itself and metabolite produce after then filtering with this device is excreted by urine flow pass 6.
This detailed description of the invention has following beneficial effect: its structure is simple, and volume is little, implantable in patient body, facilitates the treatment of dialysis patient, has widened the range of activity of patient.
Claims (1)
1. an implantating biological artificial kidney device, it is characterized in that it comprises implantating biological artificial kidney body (1), renal cells layer (2), nanoscale polyethylene glycol silicon grain film (3), arterial end (4), vein end (5) and urine flow pass (6), the inside of implantating biological artificial kidney body (1) is provided with nanoscale polyethylene glycol silicon grain film (3), the arranged outside of nanoscale polyethylene glycol silicon grain film (3) has renal cells layer (2), one end of implantating biological artificial kidney body (1) is communicated with arterial end (4), the other end of implantating biological artificial kidney body (1) is connected with vein end (5), and one end of urine flow pass (6) is connected with implantating biological artificial kidney body (1).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410039297.2A CN103977465B (en) | 2014-01-27 | 2014-01-27 | A kind of implantating biological artificial kidney device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410039297.2A CN103977465B (en) | 2014-01-27 | 2014-01-27 | A kind of implantating biological artificial kidney device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103977465A CN103977465A (en) | 2014-08-13 |
| CN103977465B true CN103977465B (en) | 2016-01-27 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410039297.2A Expired - Fee Related CN103977465B (en) | 2014-01-27 | 2014-01-27 | A kind of implantating biological artificial kidney device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103977465B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10426881B2 (en) * | 2017-01-20 | 2019-10-01 | Fresenius Medical Care Holdings, Inc. | Enhanced backflow prevention in a hemodialysis device |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3878564A (en) * | 1972-04-14 | 1975-04-22 | Shang J Yao | Blood and tissue detoxification method |
| CN1469760A (en) * | 2000-10-20 | 2004-01-21 | Լ����M������˹ | Prosthesis for internal peritoneal dialysis |
| CN101505811A (en) * | 2006-08-24 | 2009-08-12 | 弗雷泽纽斯医疗保健控股有限公司 | Device for removing fluid from blood in a patient |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5902336A (en) * | 1996-10-15 | 1999-05-11 | Mirimedical, Inc. | Implantable device and method for removing fluids from the blood of a patient method for implanting such a device and method for treating a patient experiencing renal failure |
-
2014
- 2014-01-27 CN CN201410039297.2A patent/CN103977465B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3878564A (en) * | 1972-04-14 | 1975-04-22 | Shang J Yao | Blood and tissue detoxification method |
| CN1469760A (en) * | 2000-10-20 | 2004-01-21 | Լ����M������˹ | Prosthesis for internal peritoneal dialysis |
| CN101505811A (en) * | 2006-08-24 | 2009-08-12 | 弗雷泽纽斯医疗保健控股有限公司 | Device for removing fluid from blood in a patient |
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| Publication number | Publication date |
|---|---|
| CN103977465A (en) | 2014-08-13 |
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Granted publication date: 20160127 Termination date: 20170127 |