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Publication numberCN103977465 B
Publication typeGrant
Application numberCN 201410039297
Publication date27 Jan 2016
Filing date27 Jan 2014
Priority date27 Jan 2014
Also published asCN103977465A
Publication number201410039297.2, CN 103977465 B, CN 103977465B, CN 201410039297, CN-B-103977465, CN103977465 B, CN103977465B, CN201410039297, CN201410039297.2
Inventors徐高四, 黄天伦, 叶婷, 严文君, 刘惠欣
Applicant南昌大学第二附属医院
Export CitationBiBTeX, EndNote, RefMan
External Links: SIPO, Espacenet
一种植入式生物人工肾装置 An implantable bioartificial kidney device translated from Chinese
CN 103977465 B
Abstract  translated from Chinese
一种植入式生物人工肾装置,它涉及医疗用品技术领域。 An implantable bioartificial kidney apparatus, medical supplies it relates to the technical field. 植入式生物人工肾本体(1)的内部设置有纳米级聚乙烯乙二醇硅颗粒膜(3),纳米级聚乙烯乙二醇硅颗粒膜(3)的外侧设置有肾小管上皮细胞层(2),植入式生物人工肾本体(1)的一端与动脉端(4)连通,植入式生物人工肾本体(1)的另一端与静脉端(5)连接,且尿液流出通道(6)的一端与植入式生物人工肾本体(1)相连接。 Implantable bioartificial kidney inside the body (1) is provided with nanoscale particles of polyethylene glycol silicon film (3), the outer polyethylene glycol nanoscale silicon particle film (3) is provided with a tubular epithelial cell layer (2), implantable bioartificial kidney body (1) with one end of the arterial end (4) communicating implantable bioartificial kidney body (1) and the other end of intravenous end (5) is connected, and the flow of urine passage (6) one end of an implantable bioartificial kidney body (1) is connected. 它结构简单,体积小,可植入到患者体内,方便了透析患者的治疗,扩宽了患者的活动范围。 Simple structure, small size, can be implanted in a patient, to facilitate the treatment of dialysis patients, widening the scope of activities of the patient.
Claims(1)  translated from Chinese
1.一种植入式生物人工肾装置,其特征在于它包含植入式生物人工肾本体(1)、肾小管上皮细胞层(2)、纳米级聚乙烯乙二醇硅颗粒膜(3)、动脉端(4)、静脉端(5)和尿液流出通道(6),植入式生物人工肾本体(1)的内部设置有纳米级聚乙烯乙二醇硅颗粒膜(3),纳米级聚乙烯乙二醇硅颗粒膜(3)的外侧设置有肾小管上皮细胞层(2),植入式生物人工肾本体(1)的一端与动脉端(4)连通,植入式生物人工肾本体(1)的另一端与静脉端(5)连接,且尿液流出通道)的一端与植入式生物人工肾本体(1)相连接。 1. An implantable bioartificial kidney device characterized in that it comprises an implantable bioartificial kidney body (1), renal tubular epithelial cell layer (2), polyethylene glycol nanoscale silicon particle film (3), arterial end (4), venous (5) and urine outflow channel (6), implantable bioartificial kidney inside the body (1) is provided with nanoscale particles of polyethylene glycol silicon film (3), nanoscale outer polyethylene glycol silicon particle film (3) is provided with a tubular epithelial cell layer (2), one end of the arterial end of the implantable bioartificial kidney body (1) (4) communicating implantable bioartificial kidney the other end of the vein end of the body (1) (5) is connected, and the flow of urine passage ) one end of implantable bioartificial kidney body (1) is connected.
Description  translated from Chinese
一种植入式生物人工肾装置 An implantable bioartificial kidney device

技术领域 TECHNICAL FIELD

[0001] 本发明涉及医疗用品技术领域,具体涉及一种植入式生物人工肾装置及其应用。 [0001] The present invention relates to the technical field of medical supplies, particularly relates to an implantable bioartificial kidney device and its application.

背景技术 Background technique

[0002] 随着社会发展和人民生活习惯的改变,高血压和糖尿病的发生率逐年增高。 [0002] With the change of social development and people's living habits, the incidence of hypertension and diabetes increased year by year. 因而,这两种疾病最重要的共同并发症一一慢性肾功能衰竭的发病率也显著上升。 Thus, the two most important common diseases eleven complication of chronic renal failure incidence increased significantly. 慢性肾功能衰竭患者最终都要进入到尿毒症期(以下简称尿毒症)。 Chronic renal failure patients ultimately into uremia (hereinafter referred to as uremia). 目前世界上对尿毒症的治疗主要有以下三种方式:肾移植、血液透析和腹膜透析。 The world of uremia treatment mainly in the following three ways: kidney transplantation, hemodialysis and peritoneal dialysis. 由于全球范围内肾源的缺乏,导致目前不到1%的尿毒症患者能够接受肾移植手术。 Due to the lack of worldwide kidneys, resulting in the current less than 1% of uremic patients can receive a kidney transplant.

[0003] 血液透析和腹膜透析虽然能解决尿毒症患者的存活问题,但都由于其自身存在的问题而限制了其临床应用。 [0003] Although hemodialysis and peritoneal dialysis can solve the problem of survival in patients with uremia, but are due to their own problems and limits its clinical application. 比如,血液透析患者目前需要在医院内才能完成治疗,限制了患者的活动范围和上班的问题。 For example, hemodialysis patients are required to complete treatment in the hospital, limiting the scope of activities and work problems of patients. 另外,腹膜透析治疗虽然能在患者居家进行,但患者出行时需要携带大量的腹膜透析液,很不方便。 In addition, although the peritoneal dialysis patients can be at home, but when patients need to travel to carry large amounts of peritoneal dialysis fluid, very convenient.

发明内容 SUMMARY

[0004] 本发明的目的是提供一种植入式生物人工肾装置,它结构简单,体积小,可植入到患者体内,方便了透析患者的治疗,扩宽了患者的活动范围。 [0004] The object of the present invention is to provide an implantable bioartificial kidney device, simple structure, small size, can be implanted in a patient, to facilitate the treatment of dialysis patients, widening the scope of activities of the patient.

[0005] 为了解决背景技术所存在的问题,本发明采用以下技术方案:它包含植入式生物人工肾本体1、肾小管上皮细胞层2、纳米级聚乙烯乙二醇硅颗粒膜3、动脉端4、静脉端5和尿液流出通道6,植入式生物人工肾本体1的内部设置有纳米级聚乙烯乙二醇硅颗粒膜3,纳米级聚乙烯乙二醇硅颗粒膜3的外侧设置有肾小管上皮细胞层2,植入式生物人工肾本体1的一端与动脉端4连通,植入式生物人工肾本体1的另一端与静脉端5连接,且尿液流出通道6 —端与植入式生物人工肾本体1相连接。 [0005] In order to solve the problems in the background art, the present invention employs the following technical scheme: It implantable bioartificial kidney comprising a body, two tubular epithelial cell layer, the silicon nano-particles of the polyethylene glycol film 3, arterial end 4, 5 and urine venous outflow channels 6, internal implantable bioartificial kidney body 1 is provided with nanoscale silicon particles of polyethylene glycol film 3, the outer polyethylene glycol nanoscale silicon particles film 3 provided with tubular epithelial cell layer 2, implantable bioartificial kidney artery body 1 at one end of the communication terminal 4, implantable bioartificial kidney body 1 and the other end connected to terminal 5 vein and urinary outflow channel 6 - end and implantable bioartificial kidney is connected to the main body 1.

[0006] 本发明的应用方法为:它的动脉端4与肾动脉相连,尿毒症患者的血液经过本植入式生物人工肾本体1的“清洗”后经静脉端5与肾静脉相连的导管回流体内,装置内的血液在体内血压力作用下经过纳米级聚乙烯乙二醇硅颗粒膜3的滤过,形成“原尿”,纳米级聚乙烯乙二醇硅颗粒膜3类似于人类肾小球滤过膜,对于分子量大于4.2万道尔顿的分子起到很好的阻挡作用。 [0006] Application of the method of the present invention is: its end 4 is connected to the arterial and renal arteries, the blood of uremic patients to undergo the implantable bioartificial kidney "cleansing" after venous catheter 5 and the renal vein connected to body 1 vivo reflux, the blood within the device at the blood pressure in vivo after the nanoscale silicon particles polyethylene glycol filtration membrane 3, forming the "original urine", nanoscale silicon particles polyethylene glycol film 3 is similar to human kidney small ball filtration membrane, the molecular weight greater than 42,000 daltons play a very good barrier effect. 与尿毒症患者体内血液成分相比,“原尿”内基本没有大分子成分比如免疫球蛋白等,尿毒症毒素也被滤过到“原尿”中,但其内的氨基酸、葡萄糖、小分子蛋白、电解质成分和HC03等与血液相类似。 Compared with the blood components in patients with uremia, basically no macromolecular components such as immunoglobulins within the "original urine", uremic toxins are filtered to the "original urine" in, but the amino acid therein, glucose, small molecules protein, electrolytes and blood HC03 and other similar phases. “原尿”内的成分经过装置内的肾小管上皮细胞结构2重吸收,其内的氨基酸、葡萄糖、小分子蛋白、电解质成分和HC03等又被重新吸收入血,回流至体内。 Ingredients "original urine" within the structure of the device through the renal tubular epithelial cells within 2 reabsorption of amino acids therein, glucose, small proteins, electrolytes and HC03, etc. has been re-absorbed into the bloodstream, back to the body. “原尿”中的剩余代谢产物、酸性成分等则随尿液流出通道6流至膀胱而排出体夕卜。 "Original urine" residual metabolites, and other acidic component with the flow of urine to the bladder flow channel 6 is discharged body Xi Bu. 人类肾小管上皮细胞有再生功能,可不断“补充”,而凋亡的肾小管上皮细胞本身和代谢产物则随本装置滤过后产生的“尿液”通过尿液流出通道6排出体外。 Human renal tubular epithelial cell regeneration, can continue to "supplement" and apoptosis of renal tubular epithelial cells themselves and the metabolites are subsequently filtered through the unit produced "urine" excreted in the urine outflow channel 6.

[0007] 本发明具有以下有益效果:它结构简单,体积小,可植入到患者体内,方便了透析患者的治疗,扩宽了患者的活动范围。 [0007] The present invention has the following beneficial effects: It is simple, small size, can be implanted in a patient, to facilitate the treatment of dialysis patients, widening the scope of activities of the patient.

[0008] 附图说明: [0008] Brief description:

[0009] 图1为本发明的结构示意图。 [0009] FIG. 1 a schematic view of the structure of the present invention.

[0010] 具体实施方式: [0010] DETAILED DESCRIPTION:

[0011] 参照图1,本具体实施方式采取以下技术方案:它包含植入式生物人工肾本体1、肾小管上皮细胞层2、纳米级聚乙烯乙二醇硅颗粒膜3、动脉端4、静脉端5和尿液流出通道6,植入式生物人工肾本体1的内部设置有纳米级聚乙烯乙二醇硅颗粒膜3,纳米级聚乙烯乙二醇硅颗粒膜3的外侧设置有肾小管上皮细胞层2,植入式生物人工肾本体1的一端与动脉端4连通,植入式生物人工肾本体1的另一端与静脉端5连接,且尿液流出通道6 —端与植入式生物人工肾本体1相连接。 [0011] Referring to FIG. 1, the present embodiment take the following specific technical solution: it contains implantable bioartificial kidney body 1, 2, nanoscale particles of polyethylene glycol silicon film 3, the arterial end of tubular epithelial cell layer 4, 5 and urine venous outflow channels 6, internal implantable bioartificial kidney body 1 is provided with nanoscale silicon particles of polyethylene glycol film 3, polyethylene glycol nanoscale silicon particle film 3 is provided outside the kidney 2, implantable bioartificial kidney artery 1 at one end to the body of the end tubular epithelial cell layer 4 communication, implantable bioartificial kidney connected to the other end of the body 1 and the intravenous end 5, and the flow of urine channel 6 - terminus with the implant biological body 1 is connected to an artificial kidney.

[0012] 本具体实施方式的应用方法为:它的动脉端4与肾动脉相连,尿毒症患者的血液经过本植入式生物人工肾本体1的“清洗”后经静脉端5与肾静脉相连的导管回流体内,装置内的血液在体内血压力作用下经过纳米级聚乙烯乙二醇硅颗粒膜3的滤过,形成“原尿”,纳米级聚乙烯乙二醇硅颗粒膜3类似于人类肾小球滤过膜,对于分子量大于4.2万道尔顿的分子起到很好的阻挡作用,与尿毒症患者体内血液成分相比,“原尿”内基本没有大分子成分比如免疫球蛋白等,尿毒症毒素也被滤过到“原尿”中,但其内的氨基酸、葡萄糖、小分子蛋白、电解质成分和HC03等与血液相类似。 5 is connected via the venous artery and renal vein it is connected to terminal 4 and renal arteries, the blood of uremic patients to undergo the implantable bioartificial kidney "cleanse" the body 1 after: application methods [0012] This particular embodiment is the catheter body at reflux, the blood within the device at the blood pressure in vivo after the nanoscale silicon particles polyethylene glycol filtration membrane 3, forming the "original urine", polyethylene glycol nanoscale silicon particles 3 is similar to film human glomerular filtration membrane, the molecular weight greater than 42,000 daltons play a very good barrier effect, compared with the blood components in patients with uremia, basically no internal "original urine" macromolecular components such as immunoglobulins etc., uremic toxins are filtered to the "original urine", but it is similar to the amino acid therein, glucose, small proteins, electrolytes, etc., and HC03 with blood. “原尿”内的成分经过装置内的肾小管上皮细胞结构2重吸收,其内的氨基酸、葡萄糖、小分子蛋白、电解质成分和HC03等又被重新吸收入血,回流至体内。 Ingredients "original urine" within the structure of the device through the renal tubular epithelial cells within 2 reabsorption of amino acids therein, glucose, small proteins, electrolytes and HC03, etc. has been re-absorbed into the bloodstream, back to the body. “原尿”中的剩余代谢产物、酸性成分等则随尿液流出通道6流至膀胱而排出体外。 "Original urine" residual metabolites, and other acidic component with the flow of urine to the bladder flow channel 6 and excreted. 人类肾小管上皮细胞有再生功能,可不断“补充”,而凋亡的肾小管上皮细胞本身和代谢产物则随本装置滤过后产生的“尿液”通过尿液流出通道6排出体外。 Human renal tubular epithelial cell regeneration, can continue to "supplement" and apoptosis of renal tubular epithelial cells themselves and the metabolites are subsequently filtered through the unit produced "urine" excreted in the urine outflow channel 6.

[0013] 本具体实施方式具有以下有益效果:它结构简单,体积小,可植入到患者体内,方便了透析患者的治疗,扩宽了患者的活动范围。 [0013] This particular embodiment has the following beneficial effects: It is simple, small size, can be implanted in a patient, to facilitate the treatment of dialysis patients, widening the scope of activities of the patient.

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Classifications
International ClassificationA61M1/16
Legal Events
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13 Aug 2014C06Publication
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27 Jan 2016C14Grant of patent or utility model