CN1352992A - Multifunctional separator of blood plasma components - Google Patents
Multifunctional separator of blood plasma components Download PDFInfo
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- CN1352992A CN1352992A CN 00133089 CN00133089A CN1352992A CN 1352992 A CN1352992 A CN 1352992A CN 00133089 CN00133089 CN 00133089 CN 00133089 A CN00133089 A CN 00133089A CN 1352992 A CN1352992 A CN 1352992A
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Abstract
A multifunctional separator of blood plasma components is composed of separator jointer and coverse, blood plasma separator, connector of multifunctional plasma component separator, and plasma component separator. Its blood plasma separating tube and plasma component separating tube are prepared from hollow high-molecualr fibres of polysulfonate, polyether sulfone, polypseudosulfone, or polyarylic nitrile. It can be used for separating blood plasma, plasma components, plasma displacement, component blood perfusion, etc. Its advantages include high effect, safety and reliability.
Description
The present invention relates to a kind of medical medical supplies, the multifunctional separator of blood plasma components that particularly a kind of blood purification treatment uses.This product mainly is fit to carry out replacement therapy of blood plasma, is used for the single separating plasma, dual separating plasma, blood fat separates, in vain, globulin, blood plasma components separation etc. are used for the treatment of autoimmune disease, as systemic lupus erythematosus (sle), Green Pasteur syndrome, acute and chronic hepatic insufficiency, the preparation before and after the liver transplantation with keep, acute and chronic renal failure, uremia, the fat treatment etc. of dispelling of overweight people's hyperlipemia.
The Membrane Plasma Separator of prior art is the disposable blood plasma separator or the secondary separating plasma of independent structure, disposable blood plasma separator is that separation of whole blood is become blood plasma and blood cell two parts, the secondary plasma separator is according to actual needs, again separating plasma is become some compositions, plasma separator is independent structure, on a plasma separator, can not finish blood plasma components and separate.The enterprise of domestic existing production plasma separator is mainly Ningbo of Zhejiang, and used hollow fibrous membrane tube all is the polyacrylonitrile hollow fibrous membrane tubes from external import.Its price disposable (one-level) plasma separator is at 1580 yuan/, and secondary plasma separator price is 1680 yuan/.Clinically if will carry out dual separating plasma, the input basic consumable material of seance and replenish expense such as blood plasma and reached nearly more than 6000 yuan of RMB, the treatment cost is too high, in the native land for many years replacement therapy of blood plasma carry out seldom.The external company that produces the blood purification equipment enters domestic product, and its unit price is higher than the product of domestic production, and every plasma separator reaches more than 3000 yuan, is the main cause that causes domestic therapeutic plasma exchange for many years extensively not carry out.The external plasma separator of being produced also is independent disposable Membrane Plasma Separator, if will carry out dual separating plasma, just must the treatment cost be raise, limit the development of present technique with an one-level plasma separator and a secondary plasma separator.
Purpose of the present invention is exactly very to the shortcoming of above product, designs a kind of multifunctional separator of blood plasma components, and it not only can carry out disposable blood plasma separately and separates, and also can carry out blood plasma components and separate.In actual use, can reduce widely or need not external fresh plasma, dry freeze blood plasma, albumin replenishes input, and feed back with the blood plasma of patient or curer self, not only reduced the expense of using external blood plasma, and the virulence factor of having avoided external blood plasma to bring.According to the needs of curer, also can be assembled into filter for blood dialysis by medical personnel temporarily and be used for the hemodiafiltration treatment.
The present invention realizes like this; A kind of multifunctional separator of blood plasma components, feature of the present invention is by connector cover (1), connector cover nipple (2), connector cover coupling (3), angle, connector cover medial wall rubber silicon seal washer (4), connector cover medial wall gong mother (5), whole blood-plasma separator (6), the linking gong public affairs (7-1 of the shell (9) of whole blood-plasma separator (6); 7-2), the linking gong stricture of vagina (7-1) of the shell (9) of whole blood-plasma separator (6) is connected mutually with the medial wall gong mother (5) of connector cover (1), the linking gong stricture of vagina (7-2) of the shell (9) of whole blood-plasma separator (6) connects with the silicone gasket (14-1) of multifunctional separator of blood plasma components adapter (13), at the two ends, inside of the shell (9) of whole blood-plasma separator (6), useful medical binding agent bonding hollow fibrous membrane tube lateral wall and the two ends, medial wall of the shell (9) of whole blood-plasma separator (6) cut off the medical offset plate (8-1 of back formation; 8-2), at the two ends, lateral wall of shell (9), there is blood plasma to discharge side opening pipe (10-1; 10-2), hollow fibre whole blood-plasma separation membrane pipe (11) is arranged in shell (9), offside at the sidewall blood plasma tap pipe (10-2) of shell (9), plasma specimen collection tube (12) is arranged, multifunctional separator of blood plasma components adapter (13) is positioned between whole blood-plasma separator (6) and the separator of blood plasma components (18), the silicone gasket (14-1 of multifunctional separator of blood plasma components adapter (13); 14-2) lay respectively in the gasket groove of multifunctional separator of blood plasma components adapter (13), the hollow fibrous membrane tube syringe pipe (15) that is positioned on the multifunctional separator of blood plasma components adapter (13) is an overall structure with multifunctional separator of blood plasma components adapter (13), whole blood-plasma separator (6) feeds back blood tube (16) and is connected with the blood discharge pipe (17) of multifunctional separator of blood plasma components adapter (13), the blood plasma inflow pipe (19) of separator of blood plasma components (18) is the part of its shell (23), the medial wall, two ends of the shell (23) of separator of blood plasma components (18) has adhesive of medical bonding lateral wall, hollow fibrous membrane tube two ends and shell (23) medial wall, two ends to cut off the medical offset plate (20-1 that the back forms; 20-2), there is gong public affairs (21-1 the lateral wall, two ends at the shell (23) of separator of blood plasma components (18); 21-2), inside at the shell (23) of separator of blood plasma components (18), hollow fibre blood plasma components diffusion barrier pipe (22) is arranged, in the offside bottom of blood plasma inflow pipe (19) blood plasma discharge pipe (24) is arranged, discharge pipe joint (25) and collection plasma specimen plug (26), there is gong mother (28) in the medial wall portion of the connector cover (27) of separator of blood plasma components (18), bight, medial wall at the connector cover (27) of separator of blood plasma components (18), silicone rubber seal packing ring (29) is arranged, the coupling (30) of connector cover (27), nipple (31) constitute separator of blood plasma components, and whole blood-plasma separator (6) and separator of blood plasma components (18) are to be connected and the multifunctional separator of blood plasma components that constitutes according to multifunctional separator of blood plasma components adapter (13), as Fig. 1, Fig. 2, Fig. 3, Fig. 4, Fig. 5, shown in Figure 6;
The present invention realizes like this, it is characterized in that: the hollow fibrous membrane tube (11) of whole blood-plasma separator (6), can only pass through blood plasma, only allow the sidewall pores of blood plasma by hollow fibrous membrane tube, the material of hollow fibrous membrane tube can be polysulfone membrane, poly (ether sulfone) film, poly-imitative sulfone film, can also be other medical macromolecular materials such as polyacrylonitrile film; 1500～18000 of the quantity of hollow fibrous membrane tube, effectively the diffusion barrier area is 0.1～1.5m
2, and can adjust the hollow fibrous membrane tube number according to actual needs and make with actual effectively diffusion barrier area, as shown in Figure 2;
The present invention realizes like this, it is characterized in that: the hollow fibrous membrane tube (22) of separator of blood plasma components (18), its sidewall aperture is to be that purpose designs adjustment according to different sized molecules visible components in the separated plasma, its sidewall aperture size diameter scope is to determine according to the isolating blood plasma components of institute, as shown in Figure 4;
The present invention realizes like this, it is characterized in that: separator of blood plasma components (18) can be made variety classes according to the clinical practice needs with combining of whole blood-plasma separator (6), also can dock temporarily, can realize constituting the separator of blood plasma components of various types of shape, as: separate albumin, globulin, platelet, fibrin, blood fat (cholesterol, triglyceride, beta Lipoprotein, high and low density lipoprotein etc.);
The present invention can also be achieved in that and it is characterized in that: connector cover (1) and (27) at whole blood-plasma separator (6) or separator of blood plasma components (18) fit on two ends can constitute single plasma separator or separator of blood plasma components separately, as shown in Figure 7;
The present invention realizes like this, it is characterized in that: with multifunctional separator of blood plasma components adapter (13), the inboard two ends that connect a dialyser (1) and a filter (2), dialyser docks with connector cover with the two ends, the outside of filter, can constitute a kind of dialysis filter, as shown in Figure 8.
Below in conjunction with accompanying drawing the present invention is further described: the 1-connector cover among Fig. 1,2-connector cover nipple, the coupling of 3-connector cover, angle, 4-connector cover medial wall silicone rubber seal packing ring, 5-connector cover medial wall gong mother; 6-whole blood-plasma separator among Fig. 2,7-1; The linking gong public affairs of 7-2-whole blood-plasma separator shell (9), the linking gong of 7-1-whole blood-plasma separator shell (9) is public to be connected with the 5-connector cover inwall gong parent phase of connector cover (1), the public silicone gasket (14-1) with multifunctional separator of blood plasma components adapter (13) of the linking gong of 7-2-whole blood-plasma separator shell (9) connects 8-1; 8-2-is the medical offset plate with medial wall, the two ends cut-out back formation of medical binding agent bonding hollow fibrous membrane tube lateral wall and whole blood-plasma separator shell (6), 9-whole blood one plasma separator shell, 10-1; 10-2-blood plasma is discharged side opening pipe, 11-whole blood-plasma separator hollow fibrous membrane tube, 12-plasma specimen collection tube; 13-multifunctional separator of blood plasma components adapter among Fig. 3,14-1; The 14-2-silicone gasket, 15-hollow fibrous membrane tube syringe pipe, 16-whole blood-plasma separator feeds back blood tube, and the 17-separator of blood plasma components feeds back blood tube with whole blood-plasma separator and is connected; 18-separator of blood plasma components among Fig. 4,19-blood plasma inflow pipe, 20-1; The medial wall, two ends of 20-2-medical binding agent bonding hollow fibrous membrane tube lateral wall and shell (23) cuts off the medical offset plate that the back forms, 21-1; The gong public affairs at 21-2-separator of blood plasma components shell (23) two ends, the silicone gasket (14-2) of 21-1-and multifunctional separator of blood plasma components adapter (13) connects, angle, the medial wall packing ring (29) of 21-2-and connector cover (27) connects, 22-hollow fibre blood plasma components diffusion barrier pipe, 23-separator of blood plasma components shell, 24-blood plasma discharge pipe, 25-discharge pipe joint, 26-gathers the plasma specimen plug; 27-connector cover among Fig. 5, the gong mother of medial wall portion of 28-connector cover (27), 29-silicone rubber seal packing ring, the coupling of 30-connector cover (27), the nipple of 31-connector cover (27).Fig. 6 is the general assembly drawing of Fig. 1, Fig. 2, Fig. 3, Fig. 4, Fig. 5; Fig. 7 is the installation diagram of Fig. 1, Fig. 2, Fig. 5; 1-dialyser among Fig. 8,2-filter, 3-multifunctional separator of blood plasma components adapter, the dialysis filter that dialyser and filter are connected to form.
Of the present invention actively and beneficial effect be: 1. whole blood-plasma separator (6) and separator of blood plasma components (18) be combined into one and reduce widely manufacturing cost; 2. can carry out many with multifunctional separator of blood plasma components The plasma separation of kind of purpose, replacement therapy of blood plasma and can not fail or defeated self blood plasma, frozen blood in addition less Slurry, albumin etc.; 3. can be combined into multiple separator of blood plasma components with multifunctional separator of blood plasma components; 4. use connector cover (1) and (27) to can be made into independent whole blood-plasma separator and separator of blood plasma components; 5. blood The membrane area of slurry composition separator clinically can be according to actual needs because manufacture method is simple, of a great variety Interim assembling; 6. because the present invention is multifunctional separator of blood plasma components, manufacture method is easy, can be widely Reduce product cost and price, be conducive to carry out on a large scale replacement therapy of blood plasma; 7. become with multi-functional blood plasma Part separator connector (13) connects a dialyzer and pass filter, also can consist of dialysis filter, is used for dialysis Filtering therapy; 8. because the present invention makes plasma separation become the separation of multilevel blood plasma components, so open clinical Blood fat is dispelled in the conventional health care of exhibition, and the disease that control causes because of hyperlipidemia is for the mankind's good health and a long life are contributed.
Embodiment;
1, according to shown in Figure 3, be designed to the die drawing of multifunctional separator of blood plasma components adapter (13), processing and manufacturing goes out the mould of multifunctional separator of blood plasma components adapter (13), adopt medical Merlon or other medical high polymer case material, process multifunctional separator of blood plasma components adapter (13);
2, according to Fig. 1, requirement shown in Figure 5, be designed to multifunctional separator of blood plasma components connector cover (1) and (27) processed mould figure, processing and manufacturing goes out connector cover (1) and (27);
3, according to requirement shown in Figure 2, be designed to the die drawing of the shell (9) of whole blood-plasma separator (6), processing and manufacturing goes out the mould of whole blood-plasma separator shell (9); Whole blood-plasma separator is assembled out in manufacturing;
4, according to requirement shown in Figure 4, be designed to shell (23) die drawing of separator of blood plasma components (18), process mould, manufacture the shell (23) of separator of blood plasma components (18);
5, according to the requirement of whole blood-plasma separator (6) and separator of blood plasma components (18),, use the spinning apparatus of special-purpose spinning hollow fiber silk to go out the hollow fibrous membrane tube silk with the method for spinning to hollow-fiber film; The hollow fibrous membrane tube silk of the hollow fibrous membrane tube silk of whole blood-plasma separator and separator of blood plasma components is respectively charged in the shell (9) of whole blood-plasma separator (6), and in the shell (23) of separator of blood plasma components (18), adopt the two ends of the shell (9) of medical adhesive embedding whole blood-plasma separator (6), and the two ends of the shell (23) of separator of blood plasma components (18), the two ends of hollow fibre diffusion barrier pipe (11) and (22) and the medial wall, two ends of shell (9) and (23) are become one, cut off unnecessary hollow fibrous membrane tube and the medical glue in two ends, make the hollow fibrous membrane tube pipe port open, whole blood-plasma separator (6) and the separator of blood plasma components (18) made are connected with multifunctional separator of blood plasma components adapter (13) respectively, connect connector cover (1) and connector cover (27), pack multifunctional separator of blood plasma components with inner packing and outer package, after the gamma-radiation sterilization, promptly can be used for the separating plasma treatment.
6, according to shown in Figure 8, a dialyser (1) is connected with multifunctional separator of blood plasma components adapter (13) with filter (2), can constitute dialysis filter, promptly can be used for the dialysis filtration treatment after the package sterilization.
Claims (6)
1, a kind of medical multifunctional separator of blood plasma components, the present invention is by connector cover (1), connector cover nipple (2), connector cover coupling (3), angle, connector cover medial wall silicone rubber seal packing ring (4), connector cover medial wall gong mother (5), whole blood-plasma separator (6), the shell (9) of whole blood-plasma separator (6) are connected gong public affairs (7-1; 7-2), the shell (9) of whole blood-plasma separator (6) is connected gong stricture of vagina (7-1) and is connected mutually with the medial wall gong mother (5) of connector cover (1), at the two ends, inside of the shell (9) of whole blood-plasma separator (6), useful medical binding agent bonding hollow fibrous membrane tube lateral wall and shell (9) two ends, medial wall of whole blood-plasma separator (6) cut off the medical offset plate (8-1 of back formation; 8-2), the two ends in shell (9) lateral wall have blood plasma to discharge side opening pipe (10-1; 10-2), hollow fibre whole blood-plasma separation membrane pipe (11) is arranged in shell (9), discharge the offside of side opening pipe (10-2) at shell (9) sidewall blood plasma, plasma specimen collection tube (12) is arranged, multifunctional separator of blood plasma components adapter (13) is positioned between whole blood-plasma separator (6) and the separator of blood plasma components (18), the silicone gasket (14-1 of multifunctional separator of blood plasma components adapter (13); 14-2) lay respectively in the gasket groove of multifunctional separator of blood plasma components adapter (13), the hollow fibre pipe syringe pipe (15) of multifunctional separator of blood plasma components adapter (13) is an overall structure with multifunctional separator of blood plasma components adapter (13), whole blood-plasma separator (6) feeds back blood tube (16) and is connected with the blood discharge pipe (17) of multifunctional separator of blood plasma components adapter (13), the blood plasma inflow pipe (19) of separator of blood plasma components (18) is the part of shell (23), the medial wall, two ends of the shell (23) of separator of blood plasma components (18) has adhesive of medical bonding hollow fibrous membrane tube lateral wall and shell (23) medial wall to cut off the medical offset plate (20-1 that the back forms; 20-2), there is gong public affairs (21-1 at the two ends at the shell (23) of separator of blood plasma components (18); 21-2), inside at the shell (23) of separator of blood plasma components (18), hollow fibre blood plasma components diffusion barrier pipe (22) is arranged, counter-lateral quadrents at blood plasma inflow pipe (19) has blood plasma discharge pipe (24), discharge pipe joint (25) and collection plasma specimen plug (26), there is gong mother (28) in the medial wall portion of the connector cover (27) of separator of blood plasma components (18), the bight, medial wall of the connector cover (27) of separator of blood plasma components (18) has silicone rubber seal packing ring (29) to be arranged in gasket groove, the coupling (30) of connector cover (27), nipple (31) constitutes separator of blood plasma components (18), the invention is characterized in: multifunctional separator of blood plasma components is to be connected according to multifunctional separator of blood plasma components adapter (13) with separator of blood plasma components (18) and to be constituted by whole blood-plasma separator (6).
2, according to the described multifunctional separator of blood plasma components of claim 1, its feature also is: blood plasma can only be passed through in the sidewall aperture of the hollow fibrous membrane tube of whole blood-plasma separator (6), only allow the sidewall pores of blood plasma by hollow fibrous membrane tube, the material of hollow fibrous membrane tube can be polysulfone membrane, poly (ether sulfone) film, poly-imitative sulfone film, can also be other macromolecule medical materials such as polyacrylonitrile; 1500～18000 of the quantity of hollow fibrous membrane tube, effectively diffusion barrier area 0.1～1.8m
2, and can adjust according to actual needs the quantity of hollow fibrous membrane tube and effectively the diffusion barrier area make;
3, according to the described multifunctional separator of blood plasma components of claim 1, its feature also is: its sidewall aperture of hollow fibrous membrane tube (22) of separator of blood plasma components (18) is to be that purpose designs and adjusts its size according to different sized molecules visible components in the separated plasma, its sidewall aperture size diameter design is at multilevel, that is: only by albumin, blood fat (cholesterol, triglyceride, beta Lipoprotein, high and low density lipoprotein etc.), blood lipoprotein, globulin, platelet, fibrin etc.;
4, according to the described multifunctional separator of blood plasma components of claim 1, its feature also is: cascadeflow (18) can dock according to the clinical practice needs with combining of whole blood-plasma separator (6) temporarily, can constitute various types of separator of blood plasma components;
5, according to the described multifunctional separator of blood plasma components of claim 1, its feature also is; Connector cover (1) and (27) at whole blood-plasma separator (6) or separator of blood plasma components (18) fit on two ends can constitute single plasma separator or separator of blood plasma components separately;
6, according to the described multifunctional separator of blood plasma components of claim 1, its feature also is: with multifunctional separator of blood plasma components adapter (13), connect a dialyser and a filter, can constitute a kind of dialysis filter.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00133089 CN1352992A (en) | 2000-11-12 | 2000-11-12 | Multifunctional separator of blood plasma components |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00133089 CN1352992A (en) | 2000-11-12 | 2000-11-12 | Multifunctional separator of blood plasma components |
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| CN1352992A true CN1352992A (en) | 2002-06-12 |
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| CN 00133089 Pending CN1352992A (en) | 2000-11-12 | 2000-11-12 | Multifunctional separator of blood plasma components |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8105491B2 (en) | 2004-04-27 | 2012-01-31 | Vital Therapies, Inc. | Metabolic detoxification and method |
| CN101287509B (en) * | 2005-08-18 | 2013-04-03 | 伊利亚特医学股份有限公司 | Device for enriching and/or depleting materials in a liquid |
| CN105214156A (en) * | 2015-11-02 | 2016-01-06 | 珠海健帆生物科技股份有限公司 | Apparatus for purifying blood and system |
| CN105727622A (en) * | 2014-12-26 | 2016-07-06 | 高雄大学 | Blood separating and extracting method and device |
-
2000
- 2000-11-12 CN CN 00133089 patent/CN1352992A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8105491B2 (en) | 2004-04-27 | 2012-01-31 | Vital Therapies, Inc. | Metabolic detoxification and method |
| US8608953B2 (en) | 2004-04-27 | 2013-12-17 | Vital Therapies, Inc. | Metabolic detoxification system and method |
| CN103505766A (en) * | 2004-04-27 | 2014-01-15 | 生命治疗有限公司 | Metabolic detoxification system and method |
| CN101287509B (en) * | 2005-08-18 | 2013-04-03 | 伊利亚特医学股份有限公司 | Device for enriching and/or depleting materials in a liquid |
| CN105727622A (en) * | 2014-12-26 | 2016-07-06 | 高雄大学 | Blood separating and extracting method and device |
| CN105214156A (en) * | 2015-11-02 | 2016-01-06 | 珠海健帆生物科技股份有限公司 | Apparatus for purifying blood and system |
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