WO1992008536A1 - Procedes et systemes electriquement conducteurs pour le traitement du sang et d'autres fluides organiques et/ou fluides synthetiques avec des forces electriques - Google Patents
Procedes et systemes electriquement conducteurs pour le traitement du sang et d'autres fluides organiques et/ou fluides synthetiques avec des forces electriques Download PDFInfo
- Publication number
- WO1992008536A1 WO1992008536A1 PCT/US1991/004938 US9104938W WO9208536A1 WO 1992008536 A1 WO1992008536 A1 WO 1992008536A1 US 9104938 W US9104938 W US 9104938W WO 9208536 A1 WO9208536 A1 WO 9208536A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- blood
- electrically conductive
- tubing
- vessel
- electrically
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3601—Extra-corporeal circuits in which the blood fluid passes more than once through the treatment unit
- A61M1/3603—Extra-corporeal circuits in which the blood fluid passes more than once through the treatment unit in the same direction
Definitions
- This invention relates to novel
- the present invention provides new electrically conductive methods and systems for transferring blood or other body fluids, such as amniotic fluids, and/or synthetic fluids such as tissue culture medium from a donor to a transfusion recipient or to a storage receptacle, or for recirculating a single donor's blood or other body fluids through components of a treatment system external of the body or by implant devices for purging contaminants using a novel electrically conductive vessel for direct electric treatment of blood or other body fluids, such as amniotic fluids, with electric field forces of appropriate electric field strength to attenuate such
- the new methods and systems according to the invention achieve these ends without requiring time consuming and expensive processing procedures and equipment in addition to those normally required in the handling of blood or other body fluids or synthetic fluids.
- the invention achieves the electric field force treatment during the normally occurring transfer processing from a donor to a recipient or to a collection receptacle, or recirculation of a single donor's blood or other body fluids, such as amniotic fluids.
- Figure 6 is a diagrammatic, fragmentary, elevational view showing a different modification of a novel blood transfer system using the novel electrically conductive tubing treatment vessel, and which employs a blood pump and a blood flow regulator;
- Figure 7 is an enlarged cross sectional view, similar to Figure 2 that shows an
- Figure 10 illustrates the details of construction of a somewhat different form of miniaturized electrified treatment tubing for use in an implanted treatment system of the type shown in Figure 8 and built according to the invention
- Figure 12 is a perspective top and side view of a novel electrified, closed, octagonally- shaped, flat, box-like treatment vessel having an enlarged cross sectional area relative to the cross sectional diameter of the inlet and outlet tubes supplying the interior of the treatment vessel;
- Figure 14A is a cross sectional view of Figure 14 taken through plane A-A;
- Figure 15A is a cross sectional view of the treatment vessel shown in Figure 15 taken through plane A-A of Figure 15;
- FIG 16 is a perspective view of still another form of enlarged cross sectional area treatment vessel according to the invention wherein the treatment vessel comprises a relatively large block of insulating material having parallel, longitudinally extending, open ended tubes formed through its length.
- the tubes are provided with electrically separated, opposed, parallel extending conductive plate electrodes which have opposite polarity electric potentials applied thereto.
- the ends of the tubes open into and are supplied from, or supply, respective reservoirs formed on the respective ends of the central block of insulating material containing the tubes, with inlet and outlet conduits for body fluids to be treated connected to the free ends of the respective reservoirs;
- Figure 17 is a perspective view of an enlarged cross sectional area treatment vessel similar to Figure 16 wherein the body of the treatment vessel is cylindrical in nature;
- Figure 19 is a diagrammatic, fragmentary elevational view of still another human blood or other body fluid, closed loop, recirculating treatment system according to the invention designed for use with the enlarged diameter fluid treatment vessels illustrated in Figures 12-16, and which employs both inlet and outlet fluid pumps on each side of the treatment vessel.
- the system can be operated in an intermittent manner to allow batch treatment of the body fluids to fully take place before passage of the body fluids being treated back to the patient;
- Figure 20 is a partially disassembled, perspective view of a non-flow through, single batch, body fluid treatment vessel according to the invention which is open to atmosphere on the upper side thereof to allow a clear view of the body fluids being treated during operation of the process;
- Figure 1 is a schematic illustration of one form of novel blood transfer system according to the invention.
- Figure 1 shows an electrically conductive blood treatment vessel constructed according to the invention which is in the form of intravenous-type tubing 11 interconnected between a hypodermic needle 12 and a blood storage receptacle 14.
- the needle 12 is inserted in an artery or vein of the arm 13 of a blood donor and the tubing 11 leads from the arm 13 to the receptacle 14.
- a plurality of physically separated, electrically conductive surface segments form opposed, parallel electrodes shown at 16 and 16A on the inside of tubing 11 from electrically conductive materials such as platinum, platinum alloys, silver, silver or platinum covered alloys, or other similar conductive materials such as conductive polymers, or silver or platinum covered polymers which are compatible with human fluids and tissue.
- electrically conductive materials such as platinum, platinum alloys, silver, silver or platinum covered alloys, or other similar conductive materials such as conductive polymers, or silver or platinum covered polymers which are compatible with human fluids and tissue.
- the spacing between opposed electrodes 16 and 16A is of the order of 1 to 19 millimeters and perhaps may be more or less dependent upon the application and the conductivity of the body fluids being treated.
- the electrically conductive surface segments 16 and 16A all comprise longitudinally extending, zebra-like stripe or strip electrodes which extend
- a first set of alternate electrically conductive surface stripes 16 are electrically connected in common to a first annular terminal buss 18 which circumferentially surrounds the tubing 11 and is embedded within the sidewalls of the tubing 11 at a suitable point along its length.
- the design is such that the first annular terminal buss 18 is electrically isolated from the remaining second set of
- a second annular terminal buss 21, which circumferentially surrounds the tubing 11, is embedded within the tubing 11 at a point along its length displaced from the position of the first annular terminal buss 18 and is spaced inwardly towards the inside diameter of the tubing relative to the first annular buss 18.
- the second annular terminal buss 21 is provided with an outside terminal conductor connection 22 for connecting the annular buss 21 to a negative polarity source of electric potential on the battery 20 as shown in the system drawing of Figure 1.
- the second set of alternate electrically conductive surface stripes 16A are all provided with internal connector studs which physically and electrically connect all of the 16A stripes in common to the second annular terminal buss 21 so that all of these conductive stripes will be maintained at a negative polarity potential opposite to that from the positive polarity potential applied to the first set of electrically conductive stripes 16 by annular buss 18.
- the source of electric potential may constitute a direct current voltage battery 20 connected to the conductor terminals 19 and 22 through electric supply
- conductors 23 and 24 preferably by a double pole, double throw, on-off control switch 25.
- hypodermic needle is inserted into a vein in the donor's/recipient's arm and blood is withdrawn, given, or recycled through tubing 11.
- microampere per square millimeter (l ⁇ A/mm 2 ) of electrode cross sectional area exposed to the fluid to abou t one mi lliampere per square millimeter ( 1 mA/mm 2 ) dependent upon field strength of the electric field gradient existing between electrodes 16 and 16A, the distance between the electric electrodes 16 , 16A and the conductivity
- Effectiveness is dependent primarily upon length of time of treatment (which may range from about one to twelve minutes) and the magnitude of the
- segments 16, 16A may be electro-deposited
- FIG 6 is a diagrammatic, fragmentary, elevational view of a modified blood transfer system using the novel electrically conductive treatment tubing in accordance with the invention.
- a blood pump 28 of conventional, commercially
- a separate source of excitation current for running the blood pump 28 is provided from a conventional 110 volt alternating current source through the input terminals 31, 31A.
- Figures 4 and 5 of the drawings show another embodiment of the invention wherein the electrically conductive treatment tubing 11 includes electrically conductive electrode segments 32 and 32A which are in the form of zebra stripes that extend radially around the inside diameter of tubing 11 in spaced-apart, alternating polarity, conductive annular bands 32 and 32A separated by insulating surface bands 11I which serve to
- the first set of alternate ones of the electrically conductive annular stripes 32 are electrically connected in common to a first longitudinally extending terminal buss bar 33 that is embedded within tubing 11 in parallel with the longitudinal axis of the tubing and electrically isolated from the remaining second set of alternate electrically conductive annular stripes 32A.
- the first longitudinally extending terminal buss bar 33 is designed for connection to a first polarity (positive) source of electric excitation potential through a supply conductor connection 35 on the exterior surface of the tubing 11.
- a second longitudinally extending terminal buss bar 34 is. embedded within the body of tubing 11 and is electrically connected to the remaining second set of alternate electrically conductive annular stripes 32A.
- the second longitudinally extending terminal buss bar 34 is electrically isolated from the first longitudinally extending terminal buss 33 and the first set of alternate electrically annular stripes 32.
- Terminal buss bar 33 is designed for connection to a second polarity (negative) source of electric excitation potential of opposite polarity from that of the first polarity source of excitation potential.
- an input supply conductor connection 36 is directly connected through the exterior surface of tubing 11 and to the second longitudinally
- a blood transfer system employing the embodiment of the invention shown in Figures 4 and 5 would be electrically excited in advance of injection of the hypodermic needle 12 into the arm of a blood donor so that all blood passing through the tubing 11 will be subjected to electric forces produced between the alternate polarity annularly formed conductive bands 32 and 32A.
- the length of the electrified field as related to the flow of blood through electrified tubing 11 should correspond to at least the 1-6 minute treatment time mentioned earlier.
- Figure 7 of the drawings is a cross sectional view of another embodiment of the invention.
- Figure 8 is a fragmentary, diagrammatic, elevational view showing a form of blood treatment system according to the invention wherein a small electrically conductive vessel 41 in the form of a short piece of electrified tubing and a
- implanted treatment system that comprises an integral part of the circulatory system of the patient being treated. Because the parameters of such an implanted system are necessarily small, a single passage through the implanted electrified tube 14 may accomplish a relatively small
- Figure 9 is a partial, fragmentary, sectional view of the upper arm portion 13 of a vein or artery of a patient in which a treatment system according to the invention has been
- the electrified vessel 41 is in the form of an outer housing 45 that is in the shape of a football which is implanted within the interior walls 44 of an artery or a vein 44.
- the outer housing 45 is comprised by a central, cylindrically-shaped portion 45M of solid conductor such as platinum which is
- a biocompatible with human blood and tissue has integrally formed, conically-shaped porous ends 45C which are attached to and form an electrically conductive screen grid (at the same potential) as the mid portion 45M.
- the conical end portions 45C both are perforated and may be in the nature of a screen or mesh wire and of the same material composition as the mid portion 45M.
- Disposed within the outer housing 45 is a inner housing 46 which is tear-drop shaped and secured within the central portion 45M of the outer housing by
- the inner housing 46 likewise is formed from platinum or other suitable biocompatible conductive material and has supported within its interior a
- miniaturized battery 42 secured to the conductive walls of inner housing 46 by conductive support legs 48.
- the support legs 48 serve as terminal connectors from one terminal of battery 42 to the inner housing 46 so that it is maintained at one polarity excitation potential.
- the remaining opposite polarity terminal of miniaturized battery 42 is connected through an insulated conductor 49 to the central portion 45M of outer housing 45 whereby the entire outer housing including the meshed conical end portions 45C are maintained at the opposite polarity potential.
- Figure 10 is a fragmentary, diagrammatic view of a partial vein or artery 44 showing in greater detail the cylindrical or tubular
- This implant treatment vessel 41 is miniaturized so that it is in effect an open-ended cylinder in shape and has a diameter comparable to that of a large vein or artery and so that it can be grafted or implanted into the vein or artery as illustrated in Figure 10.
- the tubular treatment vessel 41 may be
- the battery source of power 42 is annular in shape and is slipped over the tubular treatment vessel 41 in the manner shown.
- Figure 10 only a cross
- FIG. 10 sectional view of the annular collar-shaped battery 42 is illustrated.
- the respective positive and negative terminals of the battery are exposed to engage the corresponding positive and negative supply terminals 19 and 22 of the tube 41 so that the resulting battery powered structure has a minimum exterior profile to facilitate implantation.
- Figure 10 treatment vessel introduces some flow restriction in the vein or artery in which it is implanted and for this reason the construction shown in Figure 10 is preferred.
- FIGS 11 and 11A of the drawings illustrate a construction for the electrified treatment vessel 51 wherein the treatment vessel is in the form of square or rectangular cross
- treatment tubing 51 provided with a square or rectangular shape so that provision of opposed, parallel conductive electrode surfaces 51U and 51L is greatly simplified as best seen in Figure 11A of the drawings which is a cross sectional view taken through plane 11A-11A of Figure 11.
- Figure 11A of the drawings which is a cross sectional view taken through plane 11A-11A of Figure 11.
- octagonally-shaped, conductive electrode members 63 and 64 which are separated and electrically isolated one from the other by a surrounding electric insulating gasket member 65.
- the entire structure is sandwiched together and held in assembled relation by threaded thru-pins 66 as best seen in Figure 12A of the drawings.
- the insulating gasket 65 which may be of teflon defines an open space 67 between the two conductive electrode members 63 and 64, respectively, which are separated and electrically isolated one from the other by a surrounding electric insulating gasket member 65.
- the entire structure is sandwiched together and held in assembled relation by threaded thru-pins 66 as best seen in Figure 12A of the drawings.
- the insulating gasket 65 which may be of teflon defines an open space 67 between the two conductive
- Figure 13 is a perspective view of another form of enlarged cross sectional area treatment vessel 70 having an exterior shape similar to that of the treatment vessel shown in Figure 12.
- the electrified treatment vessel shown in Figure 13 differs from that in Figure 12, however, in the construction of its electrically conductive electrodes which comprise a plurality of
- the alternate set of flat electrode plates 71A are secured to and project inwardly from a
- conductive end plates 72R and 72L and coacting insulating side plates 73 which insulate the conducting end plates from one another, form an octagonally-shaped box frame which is closed by upper and lower insulating top and bottom
- the conductive end plates 72R and 72L have a central opening formed therein into which inlet and outlet tubes 76 and 77 are secured as best seen in Figure 13 for providing inlet and outlet flow through connection to the treatment vessel 70.
- the alternate sets of flat electrode plates 71 and 71A extend parallel to one another and are provided with different polarity electric
- electrified treatment vessel 70 shown in Figures 13, 13A and 13B functions in essentially the same manner as was described earlier with respect to Figures 1-7 to effect attenuation of contaminants such as bacteria, virus and fungus contained in blood and/or other body fluids being treated in the flow through treatment vessel of Figure 13.
- Figure 14 is a longitudinal sectional view of still another form of enlarged cross sectional area, electrified treatment vessel 80.
- electrically conductive electrodes 86 is embedded in and supported by the conductive end plate 82 which serves as an electrical terminal for applying electric potentials to all of the concentric electrode member 86.
- the concentric, perforated, conductive electrode member 87 is physically supported by and electrically connected to the conductive end plate 83 for the supply of an opposite polarity potential thereto.
- one or more additional perforated concentric electrode members similar to 86 may be spaced apart from the inner concentric electrode member 86 outwardly along the diameter of the circular end member 82 with additional perforated concentric electrode members 87 being sandwiched between the two electrode members 86 and spaced apart therefrom so as to provide an electric field force between all the spaced apart, separated electrically conductive electrode members 86 and 87.
- a conductive surface 89 may be formed around the interior walls of the outer, insulating cylindrical housing member 81 and electrically connected to the conductive end plate 82 or 83 which is opposite in polarity to the outermost concentric electrode members 86 or 87.
- the embodiment of the invention shown in Figure 14 and 14A operates in substantially the same manner as described with relation to earlier embodiments of the invention to assure production of biologically compatible electric current flow through the blood or other body fluid being treated in the treatment vessel 80.
- FIG. 15 is a longitudinal sectional view of still another embodiment of an enlarged cross- sectional area treatment vessel 90.
- the treatment vessel 90 again comprises an outer, hollow, open- ended cylindrically-shaped, insulating body member 91 whose open ends are closed by electrically conductive, circular end plates 92 and 93,
- Inlet and outlet tubular openings 94 and 95 are provided through the central axial opening in the conductive end plates 92 and 93 for passage of blood and/or other body fluids being treated into the interior of the treatment vessel 90.
- the conductive end plates 92 and 93 have respective sets of opposite polarity potential needle-like electrodes 96 and 97, respectively, projecting therefrom inwardly into the interior of the treatment vessel 90. Different polarity
- a conductive coating similar to that shown at 89 in Figure 14 can be provided to the inner surface of the hollow, cylindrically-shaped outer body member 91 of treatment vessel 90.
- Figure 15A is a cross sectional view taken through plane A-A of Figure 15 and shows how the array of needle-like electrodes appear within the interior of the treatment vessel 90. In operation, the treatment vessel 90 will function in
- Figure 16 is a perspective view of still another form of enlarged cross sectional area treatment vessel 100 according to the invention and Figure 16A is a partial cross sectional view taken through plane 16A-16A of Figure 16.
- the treatment vessel 100 comprises a relatively large
- insulating material which is biocompatible with blood and/or other human body fluids.
- insulating block 101 has a plurality of parallel, longitudinally extending, open-ended, tubular-shaped openings 102 formed therein through the entire length of the block.
- the tubes 102 are provided with electrically isolated, opposed, parallel extending conductive plate electrodes, best seen in Figure 16A, which have opposite polarity electric potentials applied thereto.
- One set of these electrodes formed for example by the lower electrode 109 in each tube, extend out to and engage a conductive surface coating formed on one end of the insulating block, for example 101R, and the remaining upper electrodes 109 form a second set which extend out of the left hand end of the tubes and contact a conductive coating formed on the remaining end 101L of block 101.
- Respective, opposite polarity electric potentials are supplied to the respective conductive surfaces 101R and 101L so that a potential difference exists between the sets of positive and negative polarity electrodes within each longitudinally extending tube in block 101.
- the ends of the tubes 102 open into and are supplied from, or supply, respective header
- each of the reservoirs 103 and 104 has a centrally formed opening for receiving either an inlet tube 105 applied to header 103 or an outlet tube 106 secured to header 104 for supply of blood or other body fluids to be treated to and from the treatment vessel 100.
- a blood pump or other fluid pump can be inserted between the supply tube 105 and header 103, or between outlet tube 106 and the or outlet from the header reservoir 104, or both.
- both inlet and outlet pumps can be used. In operation, the electrified
- treatment vessel 100 shown in Figure 16 functions in the same manner as those species of treatment vessels described previously.
- vents such as shown at 107 and 108 in Figure 16 to the inlet reservoir 103 and/or the outlet reservoir 104 with the vents that can be selectively operated by valves that can be automatically or manually controlled for venting off gases that might be trapped in the tops of reservoirs and which otherwise might interfere with the proper operation of the electrified treatment vessel.
- suitable venting apparatus may be provided to other of the large cross sectional area electrified treatment vessels described previously.
- Figure 17 is a perspective view of still another enlarged cross-sectional area treatment vessel 110 which is similar in all respects to the treatment vessel shown in Figure 16 with the exception that the body or block of insulating material 101 through which the elongate tubular openings are made, is cylindrically shaped as illustrated in Figure 17.
- the embodiment of the invention shown in Figure 17 would be identical to Figure 16 in the fabrication and operation of its component parts including the reservoir headers 103 and 104 and would operate in a similar manner.
- Figure 18 is a diagrammatic, sketch of a human blood or other body fluid treatment system employing one of the larger cross-sectional dimension fluid treatment vessels 60, such as any one of those shown in Figures 12-17 of the
- FIG. 18 The particular fluid treatment system shown in Figure 18 is for a continuous flow-through recirculating body fluid treatment wherein blood is withdrawn from the arm 13 of a patient and supplied through IV tubing 111 to a commercially available blood pump 28 and thence to an electrified
- the treatment vessel 60 may be like any of the treatment vessels described with relation to Figures 12-17 of the drawings wherein the blood or other body fluid being treated is exposed to a low voltage, low current electric current flow for attenuating to the point of rendering them ineffective, any contaminants entrained in the blood, such as bacteria, virus and fungus.
- the treated blood appearing at the output of the treatment vessel 60 then is recirculated back through IV tubing 112 to the arm 13 of the patient whose blood or other body fluid is being treated.
- IV tubing 111 and 112 could also be treatment tubing such as described in Figures 1-7 and 11. This could provide double treatment for the fluid if that were desirable. In the event that the entire treatment does not take place in an air conditioned, temperature controlled room, then it may be desirable to provide a
- the system of Figure 18 would be used in a continuous flow-through recirculating treatment system wherein blood from the patient's arm 13 is supplied through pump 28 to the treatment vessel 60 where it is treated and then discharged back through tubing section 112 to the arm of the patient.
- the flow rate of the blood thus processed would be adjusted to correspond substantially to the natural flow rate of blood circulated through the patient's body to the extent possible.
- the blood pump is intermittently stopped to allow for more extended electrical treatment of the blood or other body fluid contained in the
- Figure 19 is a diagrammatic sketch of a form of closed loop, flow-through recirculating treatment system according to the invention that is somewhat similar to the system shown in Figure 18.
- Figure 19 differs from Figure 18 in that an inlet pump 28 and an outlet pump 28' are connected to, respectively, the intake to and outlet from the electrified treatment vessel 60.
- an inlet control valve 113 and an outlet control valve 114 also can be interconnected between the inlet pump 28 and the intake to the treatment vessel 60 and between the output from the treatment vessel 60 and the intake to the outlet blood pump 28'.
- These inlet and outlet control valves indicated at 113 and 114 preferably, are automatically operated in a time sequence which allows the system of Figure 19 to be operated as a two pump, start-stop flow through system.
- the first pump 28 When operated in this manner, the first pump 28 is allowed to operate and discharge blood from the arm 13 of the patient to be pumped into the treatment vessel 60 and thereafter is closed off with both the inlet and outlet valves 113 and 114 in their closed condition. At this point electrification treatment of the blood or other body fluid takes place for a predetermined, scheduled time period to assure adequate
- outlet valve 114 is opened and outlet pump 28' actuated to return the treated blood to the arm of the patient 13. Operation in the semi-continuous, start-stop, batch fashion will assure that adequate electrified treatment of the blood has been
- Figure 20 is a partially disassembled. perspective view of a non-flow-thru, single batch, body fluid treatment vessel 120 according to the invention, which is open to atmosphere on its upper side, and which was used in conducting the
- FIG. 20A is a diagrammatic sketch of the assembled treatment vessel 120 shown in Figure 20 connected to a source of direct current electric power 128.
- Power source 128 was capable of providing substantially constant voltage across the conductive electrodes of the treatment vessel 120 at a given voltage setting, ranging between 0.2 volts and 12 volts DC, and for a given electrical resistivity of a sample being treated, and provided essentially constant current through the batch sample in the treatment vessel.
- the parts Upon being assembled together with through bolts and nuts 124N that extend through the openings 124 in each of the teflon partitions comprising end walls 121 and 122 and a central partition 123, the parts form a fluid-tight chamber as shown in Figure 20A.
- a set of spaced-apart, parallel electrodes 125 and 126 are supported in suitably formed
- FIG. 20A When thus assembled, the resulting structure results in a non-flow treatment vessel or cell defined by the vertically extending slot formed in a 1 millimeter wide central portion of the central segment 123 of the vessel.
- This vertically extending slot defines an open-sided treatment well 129 which is 1 millimeter across between electrodes 125 and 126, 1.56 millimeters in length and 8.32 millimeters in depth.
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9215050A GB2256439A (en) | 1990-11-16 | 1992-07-15 | Electrically conductive methods and systems for treatment of blood and other body fluids and/or synthetic fluids with electric forces |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US615,800 | 1990-11-16 | ||
US07/615,800 US5139684A (en) | 1990-08-06 | 1990-11-16 | Electrically conductive methods and systems for treatment of blood and other body fluids and/or synthetic fluids with electric forces |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1992008536A1 true WO1992008536A1 (fr) | 1992-05-29 |
Family
ID=24466854
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1991/004938 WO1992008536A1 (fr) | 1990-11-16 | 1991-07-12 | Procedes et systemes electriquement conducteurs pour le traitement du sang et d'autres fluides organiques et/ou fluides synthetiques avec des forces electriques |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0511331A4 (fr) |
JP (1) | JPH05504503A (fr) |
AU (1) | AU8725491A (fr) |
CA (1) | CA2072888A1 (fr) |
GB (1) | GB2256439A (fr) |
WO (1) | WO1992008536A1 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000013715A1 (fr) * | 1998-09-04 | 2000-03-16 | Eric Ponce | Dispositif et procede de destruction de micro-organismes notammen t par voie extracorporelle |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7052480B2 (en) * | 2002-04-10 | 2006-05-30 | Baxter International Inc. | Access disconnection systems and methods |
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US592735A (en) * | 1897-10-26 | X j john t | ||
US672231A (en) * | 1900-12-07 | 1901-04-16 | Walter Lauder | Device for the purification of water. |
US2490730A (en) * | 1946-02-12 | 1949-12-06 | Dubilier William | Device for electrically treating liquids |
US3753886A (en) * | 1971-02-11 | 1973-08-21 | R Myers | Selective destruction of bacteria |
US3878564A (en) * | 1972-04-14 | 1975-04-22 | Shang J Yao | Blood and tissue detoxification method |
US3965008A (en) * | 1974-03-15 | 1976-06-22 | Dawson Gerald C | Portable water sterilization device |
US3994799A (en) * | 1973-04-17 | 1976-11-30 | Yao Shang J | Blood and tissue detoxification apparatus |
-
1991
- 1991-07-12 CA CA002072888A patent/CA2072888A1/fr not_active Abandoned
- 1991-07-12 JP JP3516594A patent/JPH05504503A/ja active Pending
- 1991-07-12 EP EP19910917874 patent/EP0511331A4/en not_active Withdrawn
- 1991-07-12 AU AU87254/91A patent/AU8725491A/en not_active Abandoned
- 1991-07-12 WO PCT/US1991/004938 patent/WO1992008536A1/fr not_active Application Discontinuation
-
1992
- 1992-07-15 GB GB9215050A patent/GB2256439A/en not_active Withdrawn
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
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US592735A (en) * | 1897-10-26 | X j john t | ||
US672231A (en) * | 1900-12-07 | 1901-04-16 | Walter Lauder | Device for the purification of water. |
US2490730A (en) * | 1946-02-12 | 1949-12-06 | Dubilier William | Device for electrically treating liquids |
US3753886A (en) * | 1971-02-11 | 1973-08-21 | R Myers | Selective destruction of bacteria |
US3878564A (en) * | 1972-04-14 | 1975-04-22 | Shang J Yao | Blood and tissue detoxification method |
US3994799A (en) * | 1973-04-17 | 1976-11-30 | Yao Shang J | Blood and tissue detoxification apparatus |
US3965008A (en) * | 1974-03-15 | 1976-06-22 | Dawson Gerald C | Portable water sterilization device |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000013715A1 (fr) * | 1998-09-04 | 2000-03-16 | Eric Ponce | Dispositif et procede de destruction de micro-organismes notammen t par voie extracorporelle |
FR2783427A1 (fr) * | 1998-09-04 | 2000-03-24 | Eric Ponce | Dispositif et procede de destruction de micro-organismes notamment par voie extra-corporelle |
Also Published As
Publication number | Publication date |
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EP0511331A1 (fr) | 1992-11-04 |
AU8725491A (en) | 1992-06-11 |
GB9215050D0 (en) | 1992-09-16 |
GB2256439A (en) | 1992-12-09 |
JPH05504503A (ja) | 1993-07-15 |
CA2072888A1 (fr) | 1992-05-17 |
EP0511331A4 (en) | 1993-07-28 |
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