WO1999043790A1 - Method and apparatus for irradiating a biological fluid - Google Patents
Method and apparatus for irradiating a biological fluid Download PDFInfo
- Publication number
- WO1999043790A1 WO1999043790A1 PCT/US1999/004186 US9904186W WO9943790A1 WO 1999043790 A1 WO1999043790 A1 WO 1999043790A1 US 9904186 W US9904186 W US 9904186W WO 9943790 A1 WO9943790 A1 WO 9943790A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- roller
- space
- flexible container
- container
- fluid
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/08—Radiation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
- B01F31/55—Mixers with shaking, oscillating, or vibrating mechanisms the materials to be mixed being contained in a flexible bag submitted to periodical deformation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/05—Mixers using radiation, e.g. magnetic fields or microwaves to mix the material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/05—Mixers using radiation, e.g. magnetic fields or microwaves to mix the material
- B01F33/055—Mixers using radiation, e.g. magnetic fields or microwaves to mix the material the energy being particle radiation working on the ingredients or compositions for or during mixing them
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/04—Inactivation or attenuation; Producing viral sub-units
Definitions
- the present invention relates generally to a method and apparatus for
- the present invention relates to an apparatus and method that improves the efficiency and uniformity of irradiating a biological fluid
- HBV Hepatitis B
- HCV Hepatitis C
- HCV Human T Lymphotrophic Retrovirus Type 3
- HTLV Human Immunodeficiency Virus
- HIV Human Immunodeficiency Virus
- LAV Virus
- viruses in blood and blood fractions include (1) treatment with a chemical disinfectant
- furocoumarins psoralens
- analogs thereof Meruelo et al. [Proc. Nat. Acad. Sci.
- Phenothiazine dyes are pliotochemicals that bind to nucleic acids. Under
- activation conditions such as long-wavelength UV irradiation, phenothiazine
- dyes are believed to crosslink the D ⁇ A and R ⁇ A strands in viruses, thereby disabling
- Psoralens are in some ways similar to phenothiazines in that activation with
- UV irradiation crosslinks the D ⁇ A and R ⁇ A strands in viruses, thereby disabling uncoiling and replication.
- preliminary intercalation complex is formed between the psoralen and two base pairs
- psoralens 2 hypericin, etc. are best activated by either ultraviolet, visible and infrared
- wavelength light components For example, depending on the type of blood product
- the present invention includes an apparatus for illuminating a fluid having
- photosensitive material therein comprising a surface.
- a roller is separated from the
- the space is adapted to receive a flexible container.
- a light source is adapted to transmit light to the space to illuminate the fluid and react
- Another feature of the present invention may relate to a second roller juxtaposed from the roller and separated from the surface by a second space.
- Still another feature of the present invention may concern a second roller
- the second roller and second support roller are separated by a second space
- the invention also provides for a method of inducing a photoreaction of a
- photosensitive material within a fluid in a flexible container comprising: placing the
- Yet another feature of the invention may include translating the container
- mixing without having to compromise a closed system, unlike external pumping circuits and special thin-channel chambers intended to be the illumination cell. Also, mixing may be enhanced by repeated forward and reverse or reciprocating translation
- red blood cells such as red blood cells and the like.
- FIG. 1 is a side view of an embodiment of the apparatus in accordance with
- roller spaced from a surface.
- FIG. 2 is another view of the embodiment shown in FIG. 1, here with the
- FIG. 3 is a further view of the embodiment shown in FIG. 1 with the
- FIG. 4 is a side view of another embodiment of the invention depicting a
- FIG. 5 is a side view of a further embodiment in accordance with the features
- FIG. 6 is yet another embodiment in accordance with the features of the
- FIG. 7 is a reduced size top view of the invention shown in FIG. 2.
- FIG. 8 is partially enlarged cut away side view taken along the line 8-8 in
- FIG. 7 depicting still another embodiment of a roller of the invention, here including
- FIG. 9 is a side view of yet another embodiment of a roller, in accordance
- FIG. 10 is a side view of still another embodiment of a roller, in accordance
- the figures show the apparatus 10 for illuminating a
- fluid 12 having a photosensitive material typically within a fluid or biological liquid
- the apparatus comprises a surface 16 for supporting a
- the container 22 houses the fluid 12. Excellent results are
- the fluid 12 comprises a biological fluid, and in particular, blood.
- blood bag for holding blood therein, and in particular a standard type blood bag as known and used in the art, where blood or biological liquid is collected and stored by
- a roller 18 is separated from the surface 16 by a space 20.
- the -9- roller and the surface are orientated in relation to each other such that the flexible container can be translated through the space 20.
- the roller could be fixed and the surface could be fixed wherein rotation of the roller translates the bag through the space.
- the roller could be fixed and
- the surface could be movable relative to the roller whereby the movement of the
- the surface and/or rotational movement of the roller translates the bag through the space.
- the surface could be fixed and the roller rotationally, horizontally
- roller and/or surface could be any suitable roller and vertically moveable relative thereto, wherein the roller travels over the container for translation of the container through the space.
- the roller and/or surface could be any suitable roller and/or surface.
- Another embodiment of the invention as shown in the drawings may comprise a roller shaped such that the roller is not actually
- the light source need not be located interiorly of the roller 18 as discussed hereafter.
- the surface and/or the roller(s) may move in a reciprocating fashion
- the light source can be located interiorly of the roller. Additionally, the light source can be located interiorly of the roller. Additionally, the light source can be located interiorly of the roller. Additionally, the light source can be located interiorly of the roller.
- roller may have a light transmissive outer surface 26 wherein light can travel from the -10- light source through the light transmissive outer surface and to the flexible container.
- the light source could be located other than within the roller. Then, light would be transmitted to the fluid-
- the light source 24 may transmit various wavelengths of light covering UV, visible and infrared regions, depending on the photosensitive material utilized as well
- roller may include is temperature control means, see
- the temperature of the container 22 may be at least partially
- temperature control medium 46 such as a gas or a liquid. Together these two components act as a heat transfer medium for heating or cooling the flexible container
- Another aspect of the invention enables the space 20 to be adjusted. Excellent
- the source and the flexible container is also dependent on other factors, for example, the photosensitive material in the fluid, the wavelength of light utilized, its intensity and
- photoreactions are
- the surface may include a reflective characteristic wherein light passing through the flexible container and the fluid therein is reflected
- FIG. 4 the utility of such an embodiment is shown whereby multiple containers can
- Yet another embodiment of the invention includes the surface 16 comprising a
- the roller 18 and/or the support roller 32 may rotate to
- This second roller and second support roller combination with the roller and support roller can provide additional illumination and translation of the container.
- roller 34 and second support roller 40 are typically generally constructed the same as
- roller 18 The difference between these rollers is typically, substantially their
- rollers may exist.
- a second roller 34 is
- the second roller is separated from the surface 16 by a
- the apparatus is used by placing the flexible container into the space 20
- a further step to this method includes
- FIG. 5 A further embodiment of the method of the invention (see generally FIG. 5)
- the second roller is spaced from the surface 16 wherein the flexible container contacts the second roller
- the container 22 may be further enhanced by translating the container through the
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU28798/99A AU2879899A (en) | 1998-02-26 | 1999-02-26 | Method and apparatus for irradiating a biological fluid |
JP2000533530A JP2002504363A (en) | 1998-02-26 | 1999-02-26 | Method and apparatus for irradiating biological fluid |
EP99909632A EP1056837A4 (en) | 1998-02-26 | 1999-02-26 | Method and apparatus for irradiating a biological fluid |
CA002321995A CA2321995A1 (en) | 1998-02-26 | 1999-02-26 | Method and apparatus for irradiating a biological fluid |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7601998P | 1998-02-26 | 1998-02-26 | |
US60/076,019 | 1998-02-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1999043790A1 true WO1999043790A1 (en) | 1999-09-02 |
Family
ID=22129428
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/004186 WO1999043790A1 (en) | 1998-02-26 | 1999-02-26 | Method and apparatus for irradiating a biological fluid |
Country Status (7)
Country | Link |
---|---|
US (1) | US6369394B1 (en) |
EP (1) | EP1056837A4 (en) |
JP (1) | JP2002504363A (en) |
CN (1) | CN1292027A (en) |
AU (1) | AU2879899A (en) |
CA (1) | CA2321995A1 (en) |
WO (1) | WO1999043790A1 (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003090795A1 (en) * | 2002-04-26 | 2003-11-06 | Gambro, Inc. | Apparatus and method for irradiating and mixing fluids in containers |
DE202004003398U1 (en) * | 2004-03-04 | 2005-07-14 | Lutz, Peter | Transport device for biomass in a fermenter for the production of biogas and large fermenter for the production of biogas from biomass |
WO2008136371A1 (en) * | 2007-04-27 | 2008-11-13 | Toyo Seikan Kaisha, Ltd. | Cell culture apparatus, cell culture system and cell culture method |
WO2010141564A3 (en) * | 2009-06-02 | 2011-04-21 | Ceramoptec Industries, Inc. | A novel method for microbial depletion in human blood and blood products using antimicrobial photodynamic therapy |
EP3020797A4 (en) * | 2013-07-09 | 2017-03-01 | Toyo Seikan Group Holdings, Ltd. | Device for counting |
EP3135110A1 (en) | 2015-08-26 | 2017-03-01 | Universitätsklinikum Regensburg | 1,7-diaryl-1,6-heptadien-3,5-dion derivatives, methods of making and using the same |
EP3225112A1 (en) | 2016-04-01 | 2017-10-04 | Universitätsklinikum Regensburg | Photosensitiser dispersion and use of the same |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6596230B1 (en) * | 2000-01-28 | 2003-07-22 | Baxter International Inc. | Device and method for pathogen inactivation of therapeutic fluids with sterilizing radiation |
EP1693072A1 (en) * | 2002-04-26 | 2006-08-23 | Gambro, Inc., | Apparatus and method for irradiating and mixing fluids in containers |
US20060226086A1 (en) * | 2005-04-08 | 2006-10-12 | Robinson Thomas C | Centrifuge for blood processing systems |
US20070102858A1 (en) * | 2005-11-07 | 2007-05-10 | Navigant Biotechnologies, Inc. | Clamps and methods for displacing fluid from portions of fluid containers |
US8177415B1 (en) * | 2006-07-24 | 2012-05-15 | Tarpaulin.Com, Inc. | System for agitating pouched products |
DE102008053131A1 (en) * | 2008-10-24 | 2010-04-29 | Fresenius Medical Care Deutschland Gmbh | Method and arrangement for sterilizing, in particular for sterilizing an adsorber |
US11325286B2 (en) * | 2009-09-24 | 2022-05-10 | Sealed Air Corporation (Us) | Mixing machine for producing foam within a bag |
WO2011038212A1 (en) * | 2009-09-24 | 2011-03-31 | Sealed Air Corporation (Us) | Machine for producing foam within a bag |
CN204261070U (en) | 2011-11-29 | 2015-04-15 | 日光医疗有限公司 | A kind of equipment for sterilised object |
CN103184148B (en) * | 2011-12-27 | 2015-08-19 | 新奥科技发展有限公司 | Light lead device and photo bio cultivation apparatus |
WO2013106605A1 (en) | 2012-01-11 | 2013-07-18 | Terumo Bct Biotechnologies, Llc | Slidable clamp for port isolation |
US20210038802A1 (en) * | 2019-08-09 | 2021-02-11 | Fenwal, Inc. | System and method for irradiating biological fluids |
US11577016B2 (en) | 2019-08-20 | 2023-02-14 | Fenwal, Inc. | System and method for irradiating biological fluids |
DE102020205036B4 (en) * | 2020-04-21 | 2022-08-11 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Device and method for generating a liquid film of a liquid medium in a film bag, and arrangement for the controlled exposure of a liquid medium in a film bag to physical radiation |
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US4613322A (en) * | 1982-12-08 | 1986-09-23 | Edelson Richard Leslie | Method and system for externally treating the blood |
US5120649A (en) * | 1990-05-15 | 1992-06-09 | New York Blood Center, Inc. | Photodynamic inactivation of viruses in blood cell-containing compositions |
JPH05132424A (en) * | 1991-11-08 | 1993-05-28 | Nissho Corp | Ultraviolet irradiation of blood preparation containing erythrocyte |
DE4209509C1 (en) * | 1992-03-24 | 1993-06-03 | Blutspendedienst Der Landesverbaende Des Deutschen Roten Kreuzes Niedersachsen, Oldenburg Und Bremen Gemeinnuetzige Gmbh, 3257 Springe, De | Light processing device for plastic bags filled with blood plasma - has table format, table plate being formed by flat box contg. number of fluorescent tubes |
US5330431A (en) * | 1993-03-12 | 1994-07-19 | Glenn Herskowitz | Infusion pump |
US5557098A (en) * | 1994-12-20 | 1996-09-17 | Baxter International Inc. | System to identify bags disinfected by irradiation which punches holes in a polarized portion of the bag to indicate processing thereof |
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-
1999
- 1999-02-26 JP JP2000533530A patent/JP2002504363A/en active Pending
- 1999-02-26 CA CA002321995A patent/CA2321995A1/en not_active Abandoned
- 1999-02-26 CN CN99803310A patent/CN1292027A/en active Pending
- 1999-02-26 AU AU28798/99A patent/AU2879899A/en not_active Abandoned
- 1999-02-26 EP EP99909632A patent/EP1056837A4/en not_active Withdrawn
- 1999-02-26 US US09/261,602 patent/US6369394B1/en not_active Expired - Fee Related
- 1999-02-26 WO PCT/US1999/004186 patent/WO1999043790A1/en not_active Application Discontinuation
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US5587490A (en) * | 1990-04-16 | 1996-12-24 | Credit Managers Association Of California | Method of inactivation of viral and bacterial blood contaminants |
US5120649A (en) * | 1990-05-15 | 1992-06-09 | New York Blood Center, Inc. | Photodynamic inactivation of viruses in blood cell-containing compositions |
JPH05132424A (en) * | 1991-11-08 | 1993-05-28 | Nissho Corp | Ultraviolet irradiation of blood preparation containing erythrocyte |
DE4209509C1 (en) * | 1992-03-24 | 1993-06-03 | Blutspendedienst Der Landesverbaende Des Deutschen Roten Kreuzes Niedersachsen, Oldenburg Und Bremen Gemeinnuetzige Gmbh, 3257 Springe, De | Light processing device for plastic bags filled with blood plasma - has table format, table plate being formed by flat box contg. number of fluorescent tubes |
US5330431A (en) * | 1993-03-12 | 1994-07-19 | Glenn Herskowitz | Infusion pump |
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See also references of EP1056837A4 * |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003090795A1 (en) * | 2002-04-26 | 2003-11-06 | Gambro, Inc. | Apparatus and method for irradiating and mixing fluids in containers |
US7077559B2 (en) | 2002-04-26 | 2006-07-18 | Gambro, Inc. | Container or bag mixing apparatuses and/or methods |
DE202004003398U1 (en) * | 2004-03-04 | 2005-07-14 | Lutz, Peter | Transport device for biomass in a fermenter for the production of biogas and large fermenter for the production of biogas from biomass |
US9441193B2 (en) * | 2007-04-27 | 2016-09-13 | Toyo Seikan Group Holdings, Ltd. | Cell culture apparatus, cell culture system and cell culture method |
US20100075406A1 (en) * | 2007-04-27 | 2010-03-25 | Toyo Seikan Kaisha | Cell culture apparatus, cell culture system and cell culture method |
EP2141225A4 (en) * | 2007-04-27 | 2013-06-26 | Toyo Seikan Kaisha Ltd | Cell culture apparatus, cell culture system and cell culture method |
WO2008136371A1 (en) * | 2007-04-27 | 2008-11-13 | Toyo Seikan Kaisha, Ltd. | Cell culture apparatus, cell culture system and cell culture method |
EP2141225A1 (en) * | 2007-04-27 | 2010-01-06 | Toyo Seikan Kaisya, Ltd. | Cell culture apparatus, cell culture system and cell culture method |
WO2010141564A3 (en) * | 2009-06-02 | 2011-04-21 | Ceramoptec Industries, Inc. | A novel method for microbial depletion in human blood and blood products using antimicrobial photodynamic therapy |
US10330585B2 (en) | 2013-07-09 | 2019-06-25 | Toyo Seikan Group Holdings, Ltd. | Device for counting |
EP3020797A4 (en) * | 2013-07-09 | 2017-03-01 | Toyo Seikan Group Holdings, Ltd. | Device for counting |
EP3135110A1 (en) | 2015-08-26 | 2017-03-01 | Universitätsklinikum Regensburg | 1,7-diaryl-1,6-heptadien-3,5-dion derivatives, methods of making and using the same |
WO2017032892A1 (en) | 2015-08-26 | 2017-03-02 | Universitätsklinikum Regensburg | 1,7-diaryl-1,6-heptadiene-3,5-dione derivatives, methods for the prodcution and use thereof |
US11191855B2 (en) | 2015-08-26 | 2021-12-07 | Universitätsklinikum Regensburg | 1,7-diaryl-1,6-heptadiene-3,5-dione derivatives, methods for the production and use thereof |
US11938233B2 (en) | 2015-08-26 | 2024-03-26 | Universitätsklinikum Regensburg | 1,7-diaryl-1,6-heptadiene-3,5-dione derivatives, methods for the production and use thereof |
EP3225112A1 (en) | 2016-04-01 | 2017-10-04 | Universitätsklinikum Regensburg | Photosensitiser dispersion and use of the same |
WO2017167992A1 (en) | 2016-04-01 | 2017-10-05 | Universität Regensburg | Photosensitive dispersion and use thereof |
Also Published As
Publication number | Publication date |
---|---|
EP1056837A1 (en) | 2000-12-06 |
CA2321995A1 (en) | 1999-09-02 |
CN1292027A (en) | 2001-04-18 |
AU2879899A (en) | 1999-09-15 |
JP2002504363A (en) | 2002-02-12 |
US6369394B1 (en) | 2002-04-09 |
EP1056837A4 (en) | 2003-04-02 |
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