WO2000061221A1 - Method of providing cosmetic/medical therapy - Google Patents

Method of providing cosmetic/medical therapy Download PDF

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Publication number
WO2000061221A1
WO2000061221A1 PCT/US1999/028749 US9928749W WO0061221A1 WO 2000061221 A1 WO2000061221 A1 WO 2000061221A1 US 9928749 W US9928749 W US 9928749W WO 0061221 A1 WO0061221 A1 WO 0061221A1
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WO
WIPO (PCT)
Prior art keywords
electrically conductive
conductive substance
recited
electrodes
substance
Prior art date
Application number
PCT/US1999/028749
Other languages
French (fr)
Inventor
Kevin R. Orton
Original Assignee
Orton Kevin R
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to UA2001042681A priority Critical patent/UA78672C2/en
Priority to EP99965120A priority patent/EP1169082A1/en
Priority to AU31103/00A priority patent/AU777730B2/en
Priority to BR9914945-1A priority patent/BR9914945A/en
Priority to JP2000610552A priority patent/JP2002541222A/en
Priority to KR1020017012854A priority patent/KR100670096B1/en
Priority to CA002356128A priority patent/CA2356128A1/en
Priority to NZ511238A priority patent/NZ511238A/en
Application filed by Orton Kevin R filed Critical Orton Kevin R
Priority to IL14258199A priority patent/IL142581A0/en
Priority to PL350850A priority patent/PL198794B1/en
Publication of WO2000061221A1 publication Critical patent/WO2000061221A1/en
Priority to IL142581A priority patent/IL142581A/en
Priority to NO20014812A priority patent/NO20014812L/en
Priority to HK02105023.8A priority patent/HK1043326A1/en
Priority to HK02105111.1A priority patent/HK1045270A1/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Definitions

  • the present invention relates generally to providing cosmetic/medical therapy and more particularly to a method of preparing and using an electrically activated substance obtaining advantageous qualities for use in such therapy.
  • Transcutaneous electrotherapy involves the passage of an electrical current from one electrode to another, such that the therapeutic current is caused to pass through a target tissue of the patient.
  • Some exemplary devices used in the performance of transcutaneous electrotherapy are provided in United States Patent Nos. 397,474; 3,794,022; 4,180,079; 4,446,870;
  • transcutaneous electrotherapy causes electrical current to pass through the target tissue of the patient. Many patients may find this unsettling, painful or otherwise undesirable. Additionally, too much current, usually over about 1 milli-amp, can also become uncomfortable, painful, and harmful to the patient. Current also tends to concentrate near the electrodes or along current paths, which is often not desirable when trying to control the current density in tissue. In addition, the highly variable impedance nature of tissue makes it difficult to try to determine and repeat the proper treatment duration and settings.
  • the present invention provides a method for preparing a substance or solution which has unique properties. Furthermore, the substance or solution is uniquely adapted for simple, effective use. The unique physical properties are particularly useful when used in the manners described, and exhibit uniquely useful results. More specifically, molecules of the substance are thought to be forced to take on a random or unformed structure through the use of disclosed electrical energy. A technique for initiating this randomizing is disclosed. The spin, valence, structure, magnetic coupling, or bonding of the atoms is likely affected. Also disclosed is a technique for allowing very high current and energy level concentrations to occur in a solution without instigating electrolysis of the solution. Also disclosed are process time parameters, and a technique for use of the solution. The solution herein is generally termed "electrically active".
  • the electrically activated substance herein is able to cause or trigger a molecular or chemical action.
  • the electrically activated substance disclosed tends to exhibit catalyst type properties when injected in biological tissue. That is to say, it tends to trigger pre-existing response mechanisms in the tissue, rather than reacting with the tissue in a direct manner in the way a conventional drug would.
  • the electrically activated substance herein largely comprises ordinary tap water, or possibly distilled water.
  • water has many unusual properties, this invention is not necessarily limited to using water as a base or component of the solution.
  • Various other compatible substances, particularly liquids, may potentially be used for an activation solution. This might include various classes of alcohols or other chemicals.
  • Additional materials may be included or added to the substance.
  • placental, amniotic, serum, and stem cell types of structures may be added, either before, during, or especially after the application of the electrical signal.
  • addition of these or any biological or living or post-living cells are not an important or essential requirement for the practice of this invention.
  • vitamins, analgesics, and other additives may be used.
  • a thickening agent such as PEG-150 Distearate or auramidopropyl beatine may be added to provide thickening into a paste or gel or semi-solid consistency for easier application, especially when using the substance topically.
  • One step of electrically activating the substance comprises applying an electrical signal to the substance.
  • the type of signals used are important to obtaining useful results.
  • An alternating current and more particularly, a high frequency alternating current (HFAC or just AC) has been found to be a beneficial part in the process of re-structuring or randomizing the molecules or activating the solution. This is enhanced by the flow of electrons in both directions through the solution.
  • HFAC high frequency alternating current
  • one electrode is positive (+) and one electrode is negative (-).
  • a DC component in the signal will cause electrolysis to occur, which is not a desired feature of this invention.
  • This invention does not rely on conventional electrolysis of the solution to create its activation qualities. With a DC component in the signal, there would be rapid production of hydrogen and oxygen gas, and the substance will vaporize away in a matter of minutes, - before sufficient activation occurs. There will also be undesired changes in the PH level of the solution, which is not necessary when practicing this invention.
  • the PH balance of the medium will not change substantially during the activation process. This may be observed with a hand-held type digital PH meter. A typical reading is 7.2 at the start of the activation cycle, and a value of 7.1 • 7.3 at the end. (The electrical energy should be removed when making a measurement.) Of course, if the PH level should shift, as would occur with a non-symmetrical AC waveform, the shift does not necessarily mean that the solution can not be used.
  • the method of generating the electrical signals is known and consists generally of a power source, a signal generator and a high power amplifier.
  • Biological currents electron transport functions
  • a large amount of power is used on a bio-compatible material, new beneficial properties are obtained.
  • a medium functioning as an intermediate transfer solution, • is employed. Electrical signals are applied to the medium, which is then applied to the patient after removal of current therethrough. In this way more power may be used than would normally be comfortable or safe for the patient if current were to flow through the patient.
  • the minimum power density required is about 10 milliwatts per milliliter. Thus, if a 100 milliliter (about 4 oz.) batch is prepared, at least 1 watt and preferably 100 watts of power should be used.
  • an electrical signal that preferably comprises an alternating current signal operating in the frequency range of between approximately 10 KHz and approximately 1 MHz, with between approximately 25 KHz and approximately 100 KHz being optimum.
  • the gassing away of the solution is reduced by about 100 to 1000 times that of a lower frequency or DC signal.
  • phase reversals of the current flow per unit of time and orders of magnitude more current and power may be used.
  • the electron agitation is also increased over lower frequencies.
  • the atoms may be partially electrolyzed (separated), yet reco bined back together again before any gas escapes.
  • This partial electrolysis, current phase reversal, then recombining and then re-separating again may be what contribute to the substance becoming electrically activated.
  • the current reverses direction faster than molecules can be atomized, broken up, and escape, and little gassing is released.
  • the new properties that the solution takes on at the specified frequency and power levels then allow it to absorb significantly more energy than at lower frequencies. In fact, the solution can now absorb enough energy to cause electrical conduction heating of the solution. This is the ideal condition for creating the activated substance.
  • the temperature rise of the substance during activation will be approximately at least 3, 4, or 5 degrees and up to approximately 100 degrees Fahrenheit above ambient, depending on the actual power level used.
  • the frequency used is critical to the success of the device.
  • the substance will not become properly electrically activated if the correct frequency is not used.
  • the frequency range called for is the one that allows the most bio-compatible activation. For example, if a frequency of 60 hertz is used, the substance will electrolyze away in only a few minutes at the power levels called for in this invention. Additionally, the substance will just not generate the biological response that frequencies in the range specified will. At frequencies above about 1 MHz, the present medium will not take on the biological activation qualities, although there may be other mediums which will respond at that frequency. For example, applying microwave frequency energy to water will not result in biologically active activation of the substance. Thus the frequencies specified are found to work best.
  • the alternating current has approximately minimal direct current bias to prevent PH shift and gassing.
  • the electrical signal is preferably applied to the substance via a capacitor-resistor network.
  • the electrical signal is applied to the substance via an isolation transformer.
  • the electrical signal preferably has a voltage of between approximately 50 volts rms and approximately 150 volts rms.
  • the electrical signal is applied to the substance to be electrically activated via at least one pair of electrodes.
  • a plurality of pairs of electrodes may be utilized, if desired.
  • the electrodes are comprised of an electrically and biologically inert, non-reactive metal or a non-metallic material having a low atomic number and low resistance.
  • gold, carbon, and graphite-carbon material are suitable. It has been found that lead, aluminum, copper, and other metals are not recommended for the practice of this invention, as they can cause lead ions, for example, to leach into the solution, potentially poisoning the patient. Silver provides possible antibiotic, antiseptic properties to the substance, and may optionally be used or added to the substance when this is desirable.
  • multiple pairs of electrodes may be used with various different phase relationships. In this case, it may not be necessary for there to be minimal DC bias at all, as if one pair of electrodes has a positive DC bias, and another pair has a negative DC bias, the net charge bias into the solution may be near zero, thereby effectively eliminating the undesired electrolysis effect.
  • a substance When distilled water is to be electrically activated, then a substance must often be added to the water to introduce impurities therein, so as to facilitate current flow therethrough.
  • sodium chloride (salt) or minerals are added to form an electrolyte from distilled water.
  • the additive substance e.g., sodium chloride
  • the additive substance is added to the distilled water while monitoring current flow therethrough, until the desired current is obtained. This process makes it easier for the operator, and provides more consistent results.
  • approximately 1 amp rms of current is caused to flow through the substance to be electrically activated.
  • a voltage of approximately 100 volts rms is required to effect a current of 1 amp rms. It has been found that currents as low as 1 miiliamp may be used, if desired.
  • at least 10 milliwatts of power per milliliter of substance are utilized. When a large amount of power is used in the activation process, new beneficial properties are obtained.
  • the substance may be taken orally to obtain additional benefits.
  • approximately 2 ml of the electrically activated substance is preferably ingested per day for approximately 6 weeks.
  • the substance has also been found to provide useful qualities for the treatment of internal conditions if applied correctly.
  • Figure 1 shows apparatus including a variable frequency current source being utilized to electrically activate a liquid contained within a beaker
  • Figures 2 and 3 are block diagrams showing alternate configurations of the apparatus of Figure 1
  • Figure 4 is a flow chart showing the steps involved in the practice of the therapy method, according to the present invention.
  • Figure 5 illustrates one example of an alternating current waveform at the output of the current source of Figure 1.
  • Figures 6-8 and 13 illustrate the electrically activated substance being applied to biological tissue.
  • Figures 9, 10, 11 a-c, and 12a-b show tissue changes and results obtained after the electrically activated substance has been applied thereto.
  • variable frequency current source 10 is electrically connected, via wires 12, to probes or electrodes 14 which are at least partially immersed within the substance 18 to be electrically activated, which is contained within a beaker 16.
  • a fixed frequency current source may be used.
  • the variable frequency current source 10 preferably generates an output with a frequency within the range of from approximately 10 KHz to approximately 1 MHz, and a voltage output from approximately 50 volts rms to 150 volts rms, and having a maximum current output in excess of 1 amp rms, and provides preferably a generally symmetrical alternating current waveform. According to the preferred embodiment of the present invention, the variable frequency current source 10 also provides an alternating current output having minimal direct current bias, as illustrated in Figure 5 of the drawings.
  • a high frequency alternating current (AC) signal preferably having a generally symmetric waveform
  • a sinusoidal waveform is suitable, as would be a square AC waveform, a triangular AC waveform, or any odd- shaped AC waveform with preferably equal energy in each polarity.
  • a square wave generally provides the highest power and best result.
  • waveforms both symmetrical and non-symmetrical, would likewise provide alternating flow of current.
  • various other combinations of waveforms may likewise be suitable if they provide a beat or resonance or modulation signal within the 10 Khz to 1 MHz band.
  • the frequency output of the variable frequency current source 10 is capable of being swept or automatically varied between a minimum and maximum frequency.
  • the variable frequency current source 10 is capable of being manually swept in frequency.
  • the wires 12 preferably comprise copper wires having a current rating sufficient to carry the required current, e.g., 1 amp rms, without excessive heating.
  • Typical dimensions for the electrodes 14 are 3 mm thick, 20 mm wide, and 10 cm long. However, as those skilled in the art will appreciate, various different dimensions and cross-sectional configurations, e.g., round, oval, square, triangular, etc., may likewise be suitable.
  • the electrical resistance of the finished electrodes is less than 500 ohms/cm 2 , preferably less than 50 ohms/cm 2 .
  • the two electrodes are positioned several centimeters apart in a 250 ml container, e.g., the beaker 16.
  • the beaker 16 is preferably formed of a non- conductive material, such as glass or plastic.
  • the method for electrically activating the substance 18 is preferably practiced utilizing approximately 200 ml of the substance at a time.
  • the actual quantity of substance electrically activated may be varied widely by varying the dimensions of the container, electrodes, and by varying the strength of the electrical signal appropriately.
  • current flow through the substance 18 being electrically activated is monitored as an electrolytic substance is added thereto so as to form an electrolyte.
  • an electrolytic substance For example, when water is being electrically activated, then sodium chloride is added to the water, so as to form an electrolyte. As the sodium chloride is added to the water, current flow through the water may be monitored until the desired current flow is achieved, thereby indicating that sufficient sodium chloride has been added to the water.
  • approximately 1 amp rms of current is caused to flow through the substance 18 being electrically activated while a voltage of approximately 100 volts rms is applied thereto.
  • a voltage of approximately 100 volts rms is applied thereto.
  • Various other voltage and amperage levels are likewise suitable.
  • current is allowed to flow through the substance being electrically activated for approximately 4-8 hours. At this point there will usually be small gas bubbles formed upon the electrodes. At this point, the substance has been fully electrically activated and is ready to use.
  • the degree to which the substance 18 is electrically activated, and thus the effectiveness thereof, is directly related to the voltage applied to the electrodes 14, the spacing of the electrodes, the current caused to flow between the electrodes, and, to some extent, the length of time that the current is applied. As indicated in Figure 4, current must flow between the electrodes for a minimum of at least 10 minutes before any usable results are typically obtained. It is thought that the application of current for a time period in excess of 8 hours produces little additional effectiveness of the electrically activated substance. The recommended period of time is 4-12 hours.
  • the electrically activated substance is typically active for only a limited amount of time after current flow therethrough has ceased.
  • the electrically activated substance is thought to be most effective if utilized within approximately 4 hours after its production.
  • the electrically activated substance is thought to be somewhat effective for up to 4 days after its production, and almost totally diminished after 7 days. It is believed that the decay in the effectiveness of the electrically activated substance is logarithmic in nature, with more than half of the effectiveness thereof lost within approximately 24 hours. Thus it is important to use the substance promptly to derive the benefits described herein.
  • the specified values for the applied voltage, duration, and conductivity of the medium may be varied somewhat. Indeed, a reduction in the effectiveness of the electrically activated substance may be compensated for by varying one or the other of the production parameters.
  • a lower voltage may be utilized if additional sodium chloride is added to the solution. However, if too much sodium chloride is added, then the solution may become less bio-compatible. Conversely, if less sodium chloride is utilized, then a higher voltage is necessary to obtain sufficient current flow through the substance.
  • the electrically activated substance of the present invention when applied to biological tissue, initiates a weak electrical (or ionic) signal in the tissue, similar to the alert signal that occurs when a mechanical strain to the tissue has occurred. This is possibly caused by the spin, valence, or magnetic coupling or polarizing activity of the activated substance.
  • the activated substance may possibly work by loosening weak molecular bonds in the tissue, thereby causing a regeneration response as the bonds or tissues recover.
  • the activity of the substance triggers accelerated metabolic activity in the treatment area. Blood flow accelerates while cellular metabolic activity and interactions increase. As is best shown in Figures 9 and 10, capillaries and/or blood vessels 50 dilate following the treatment and there is increased cellular activity. Toxins, free radicals, metabolic waste and remnant material may be re-formed or flushed away.
  • the electrically activated substance of the present invention need not be applied to fresh injury sites. It may interfere with the timing and development of the natural current of injury, thereby inhibiting the healing process. However, once the injury has stabilized, the electrically activated substance of the present invention may be applied thereto so as to enhance or re-stimulate the healing process.
  • One use of the electrically activated substance of the present invention is the treatment of skin sagging.
  • the water is activated with a frequency of between approximately 50 KHz and 100 KHz.
  • a frequency of between approximately 50 KHz and 100 KHz When injected for this purpose, there is a uniform reduction of sagging throughout the body.
  • the recovery phase After each application, the recovery phase typically has a duration of approximately 1 to 7 days. After about
  • the substance may also be advantageously used to treat pulmonary conditions.
  • the electrically activated substance 18 is inhaled as a mist, or droplet form. This is preferably accomplished with the use of a conventional nebulizer 74 to convert the liquid to a vaporous material 72.
  • nebulizers are commercially available through various health care providers. Some models use compressed air or mechanical vibrations to convert a liquid or fluid to a fine mist.
  • One such device is sold under the trademark "Micro Air” by Omron Industries. This device brakes the liquid into small particles from approximately 1 micron to 10 microns in size. These particles are clumps of molecules.
  • the electrically activated properties of the substance are found to remain.
  • the electrically activated substance 72 is inhaled, additional advantages and benefits to the recipient are realized. For example, when inhaled as a mist, the substance may be used to beneficially treat lung and pulmonary tract problems and disorders.
  • Interstitial fibrosis occurs when lung tissue becomes scarred and loses its flexibility and elasticity. This can happen after an infection, for example, or contact with an irritant and can make breathing difficult and even painful. There may also be a loss of capillary and blood-gas (air) exchange function. This condition can be improved when the vaporous mist 72 is inhaled.
  • Figure 12a shows a cutaway patch of pulmonary fibrosis tissue 90.
  • the tissue 90 is largely composed of fibrous strands 91. There are a lack of blood vessels, and the tissue is stiff.
  • Figure 12b shows the same portion of tissue 90 after coming into contact with the vaporous mist 72 of Figure 6.
  • the mist 72 helps to soften and diminish the fibrous tissue 91 and generate new blood vessels 92, thereby helping to restore normal capillary action and lung function.
  • Emphysema occurs when air sacs (alveoli) in the lungs burst. This is the result of weakened connective tissue. It is often initiated by air pollutants.
  • the active-energy properties of the substance of this invention acts to improve the condition of the connective tissue and dislodge and remove contaminants. In this way further destruction is minimized and even some function restored.
  • Arterial plaque is another condition which is desirous to treat. This is a commonly occurring condition. It is partly influenced by diet. The plaque is largely composed of fats and lipids which have not been metabolized. These fatty deposits become attached to artery walls and surfaces and can build up over a period of time. These same fatty deposits may also build up in other tissues throughout the body.
  • the plaque can reduce the size of arterial passageways, thereby inhibiting blood flow and impairing chemical function and activity.
  • the fatty deposits may also accumulate in the body in general. This is shown in Figure 11 a.
  • the cross sectional view of an artery 122 has a build up 121 on the interior lining 123 which constricts its size, reducing the flow of blood therethrough.
  • the activated substance of the invention when prepared as described herein, has been found to possess unique capabilities resulting in an effective and useful technique of treating such a plaque condition when the substance is injected into the blood stream.
  • a syringe, catheter, or other such type of device may be used to effect the internal injection. This is shown in Figure 7.
  • a hypodermic needle 71 is attached to a syringe 73 or a container containing the electrically activated substance 18. The needle 71 is inserted through the epidermal layers of skin in order to inject the substance 18.
  • an I.V. feed may also be used.
  • a hypodermic needle 71 is attached to a tube 75 and a container 77 containing the electrically activated substance 18. The needle 71 is inserted through the epidermal layers of skin in order to inject the liquid 18.
  • Figure 11b shows the artery 122 of Figure 11a with the activated substance 18 contacting the blood 124 and the plaque 121.
  • Figure 11c shows the same artery 122 with the plaque 121 diminished in size after the treatment.
  • Figure 13 shows a hypodermic needle 81 connected to a syringe 82 that carries the activated substance to be injected through the skin of an animal.
  • Graduation marks on the syringe 73 or the IV container 77 measure the amount of activated liquid 18 to be applied in a dose.
  • the typical dose rate is one to two cc's per 100 pounds of body weight.
  • the molecular action of the electrically activated substance When taken internally as an injection or IV into the blood stream, the molecular action of the electrically activated substance then becomes useful to dissolve, soiubolize, loosen and remove fatty deposits and plaque buildup from the artery walls. This increases capillary and general blood flow and action.
  • the fatty deposits which commonly occur in the blood vessels and throughout the body and blood flow system are cleaned away and solubolized as described herein, the chemical and metabolic efficiency and effectiveness of the body thereafter increases greatly, causing significant and substantial improvements in the functioning, operation, and regeneration ability of most all body systems and processes. This will then allow the strengthening of arterial walls and improve the production of collagen and ligament type support structures.
  • the method provides a new, useful and effective treatment for plaque build up conditions and positive additional benefits. The process thus also serves to provide pain relief to the recipient.
  • the substance When used as an internal injection or IV, the substance is often best administered several times over a period of weeks or months.
  • the first few treatments may be at a lower dosage rate to avoid an excessively strong reaction the first time the product is used.
  • the substance may also be inhaled or injected along with other materials, nutrients, and drugs, without departing from the scope of this invention.
  • the electrically activated substance of the present invention functions as a transfer agent or medium, there is no current flow from the current source through biological tissue. Thus, there is no chance of bums, thereby enhancing the safety of such treatment. Further, there is no muscle contraction or nerve impulse firing as a result of using the electrically activated substance of the present invention, as is common during contemporary transcutaneous electrotherapy. Furthermore, there is substantially no removal of tissue, unlike dermabrasion and other techniques, and no acid/base effects on the body from PH shifts.
  • the substance has been found to have strong anti-viral properties, and may be used by itself or with other drugs, as well as for generally treating pain.
  • the substance is also useful in treating and repairing conditions associated with damaged and cross-linked protein structures.
  • variable frequency current source 10 does not provide approximately 0 direct current bias, then the output thereof can be processed so as to mitigate direct current bias.
  • a resistor-capacitor network 22 may be used to filter the output of the variable frequency current source 10, so as to mitigate direct current bias.
  • a resistor-capacitor network comprises at least one capacitor 26 in series with the substance 18 being electrically activated and at least one resistor 28 in parallel therewith.
  • the resistor-capacitor network 22 functions according to known principles to mitigate the presence of DC bias in the substance being electrically charged.
  • filters may be utilized.
  • a capacitor inductor network may be utilized.
  • an isolation transformer 24 isolates the substance 18 to be electrically charged from direct current bias present in the output of the variable frequency current source 10.
  • variable frequency current source 10 does not include a means for monitoring current flow through the substance 18 being electrically activated
  • such means is preferably included in the electrical path of the electrodes 14.
  • an amp meter 20 may be inserted in line or applied inductively to one of the wires 12 which provide an electrical pathway for the current which travels between the electrodes 14.
  • an oscilloscope may be utilized to monitor current flow and voltage between the electrodes 14.
  • the method for forming the electrically activated substance 18 of the present invention generally comprises the step 30 of providing distilled water, the step 32 of adding sodium chloride to the distilled water while monitoring current flow between the electrodes 14, the step 34 of applying alternating current to the electrodes 14 and the step 36 of administering the electrically activated substance, preferably within four hours after the electrical activation thereof.
  • the electrically activated substance is only administered after first discontinuing the application of current thereto.
  • the electric current can be applied to an intermediate material (i.e., the electrically activated substance), rather than directly to a person.
  • an intermediate material i.e., the electrically activated substance
  • a substantial amount of power may be applied to the electrically activated substance, without undesirable interference with biological processes which would occur if an electrical signal of strong energy were applied directly to a recipient.
  • much more power for example 100 watts, can be applied to the electrically activated substance than could comfortably be tolerated by human tissues.
  • the minimum amount of power applied to the substance during electrical activation thereof must be sufficient to overcome the activation decay rate of the substance.
  • a small activation energy will disperse as quickly as it is generating, prohibiting adequate activation of the substance. It has been found that the application of at least approximately 10 milliwatts of electrical power, and preferably 100-400 milliwatts, per milliliter of substance results in an acceptable decay rate.
  • Non-distilled or tap water or other bio-compatible compounds, including tissue products may be utilized instead of distilled water. It has been found that tap water is frequently suitable for use in the practice of the present invention. However, as those skilled in the art will appreciate, the types and amounts of impurities found in tap water vary considerably from one location to another. Thus, if an accurate analysis of the tap water to be utilized is not available, then the effectiveness and current flow therethrough may be determined by trial and error.
  • electrolyte-forming substances other than sodium chloride, are likewise suitable including but not limited to potassium, salts and minerals.
  • step 34 The application of alternating current during step 34 to the substance to be electrically activated preferably takes place for a duration of approximately 4 to 8 hours. After this amount of time, there may be small gas bubbles on the electrodes.
  • the electrically activated substance is created using the power levels, frequencies, current densities, and dosage quantities described herein. When the substance is produced in this manner, it takes on unique properties.
  • the electrically activated substance is created using the power levels, frequencies, current densities, and dosage quantities described herein, or parameters comparable to those described herein.
  • the substance is produced in this manner, it takes on unique properties (possibly on an atomic level), which make it particularly well suited for the practice of the present invention.

Abstract

A method for preparing and use of a substance (18). The preparation involves flowing an alternating electrical current through an electrolytic material. The alternating current is caused to flow for a period preferably at least 10 minutes, and more preferably 4-8 hours, so as to change a physical property thereof. The current is then removed. The substance has properties which last for a limited time. While active, the substances may then be used to provide medical/cosmetic therapy to a recipient by inhaling into the pulmonary tract, or internal injection of the substance into the body of a human or animal recipient.

Description

METHOD OF PROVIDING COSMETIC/MEDICAL THERAPY
Background of the Invention Field of the Invention
The present invention relates generally to providing cosmetic/medical therapy and more particularly to a method of preparing and using an electrically activated substance obtaining advantageous qualities for use in such therapy. Description of the Related Art
The use of transcutaneous electrotherapy to treat medicinal conditions is known. Transcutaneous electrotherapy involves the passage of an electrical current from one electrode to another, such that the therapeutic current is caused to pass through a target tissue of the patient. Some exemplary devices used in the performance of transcutaneous electrotherapy are provided in United States Patent Nos. 397,474; 3,794,022; 4,180,079; 4,446,870;
5,058,605; in French Patent 2621-827-A; and European Patent Application EP-377 057-A.
Although the use of transcutaneous electrotherapy has been around for a while, in many ways there are undesirable aspects. For example, transcutaneous electrotherapy causes electrical current to pass through the target tissue of the patient. Many patients may find this unsettling, painful or otherwise undesirable. Additionally, too much current, usually over about 1 milli-amp, can also become uncomfortable, painful, and harmful to the patient. Current also tends to concentrate near the electrodes or along current paths, which is often not desirable when trying to control the current density in tissue. In addition, the highly variable impedance nature of tissue makes it difficult to try to determine and repeat the proper treatment duration and settings. In view of the foregoing, it is desirable to provide an effective alternative to transcutaneous electrotherapy techniques wherein electric current is not required to flow through the tissue of the patient, which is also easier and simple to apply, can more evenly distribute its benefits, provide more accurate results, and is more effective.
Other existing medical procedures, including such procedures as surgical cut and lift, laser resurfacing, and chemical peels damage the outer layers of skin, which must then be renewed. This takes time, and there is risk of burning and scaring. Angioplasty for treatment of coronary circulation impairments is expensive, localized, and requires surgical techniques. Also, this procedure is expensive, requires skilled professional administration, and carries a certain degree of risk, as well as inconvenience, and generally requires a healing period.
Various existing inhalants are available for relief of symptoms of pulmonary conditions, but they often do not correct them, as so consequently require continual usage. Other existing medical drug therapy techniques have limitations which may be undesirable. Drugs work by altering, interfering with, supplementing or reacting in chemical means in the body. As such, they may exhibit potent results, but will generally require a variety of different compounds to provide a useful range of therapies. There may also be side effects. Thus it is desirable to provide a substance with drug like action, for use in a medicinal way, that is relatively simple to make, simple in structure, is easy to make and apply, has a wide range of uses, more permanent results, can provide more effective results than existing medications for many conditions, and does not cause electrical current to directly flow through the tissue of the recipient, whether a human or an animal. This invention provides such a means.
Summary of the Invention The present invention provides a method for preparing a substance or solution which has unique properties. Furthermore, the substance or solution is uniquely adapted for simple, effective use. The unique physical properties are particularly useful when used in the manners described, and exhibit uniquely useful results. More specifically, molecules of the substance are thought to be forced to take on a random or unformed structure through the use of disclosed electrical energy. A technique for initiating this randomizing is disclosed. The spin, valence, structure, magnetic coupling, or bonding of the atoms is likely affected. Also disclosed is a technique for allowing very high current and energy level concentrations to occur in a solution without instigating electrolysis of the solution. Also disclosed are process time parameters, and a technique for use of the solution. The solution herein is generally termed "electrically active".
One advantageous use of the electrically activated substance herein is in the treatment of various diseases and biological conditions. The electrically activated substance per this disclosure is able to cause or trigger a molecular or chemical action. The electrically activated substance disclosed tends to exhibit catalyst type properties when injected in biological tissue. That is to say, it tends to trigger pre-existing response mechanisms in the tissue, rather than reacting with the tissue in a direct manner in the way a conventional drug would.
According to one embodiment of the present invention, the electrically activated substance herein largely comprises ordinary tap water, or possibly distilled water. Although water has many unusual properties, this invention is not necessarily limited to using water as a base or component of the solution. Various other compatible substances, particularly liquids, may potentially be used for an activation solution. This might include various classes of alcohols or other chemicals.
Additional materials may be included or added to the substance. In particular, placental, amniotic, serum, and stem cell types of structures may be added, either before, during, or especially after the application of the electrical signal. However, the addition of these or any biological or living or post-living cells are not an important or essential requirement for the practice of this invention. Also vitamins, analgesics, and other additives may be used.
In addition, other materials may be used or added to the water or substance without departing from the spirit and scope of the invention. For example, a thickening agent, such as PEG-150 Distearate or auramidopropyl beatine may be added to provide thickening into a paste or gel or semi-solid consistency for easier application, especially when using the substance topically.
One step of electrically activating the substance comprises applying an electrical signal to the substance. The type of signals used are important to obtaining useful results.
The use of an alternating or at least heavily pulsating direct (DC) current is an important part of the invention. An alternating current, and more particularly, a high frequency alternating current (HFAC or just AC) has been found to be a beneficial part in the process of re-structuring or randomizing the molecules or activating the solution. This is enhanced by the flow of electrons in both directions through the solution.
For example, on the + portion of the waveform, one electrode is positive (+) and one electrode is negative (-).
Current will flow through the solution and, if electrically activating water, hydrogen gas will evolve at one electrode, with oxygen at the other. By reversing the polarity of the current flow (using an AC waveform) on a periodic basis, the current flow will be reversed, and the gasses evolved at each electrode will also reverse. A direct current (DC) signal current does not initiate the activation process.
In fact, a DC component in the signal will cause electrolysis to occur, which is not a desired feature of this invention. This invention does not rely on conventional electrolysis of the solution to create its activation qualities. With a DC component in the signal, there would be rapid production of hydrogen and oxygen gas, and the substance will vaporize away in a matter of minutes, - before sufficient activation occurs. There will also be undesired changes in the PH level of the solution, which is not necessary when practicing this invention.
When practicing the invention optimally, the PH balance of the medium will not change substantially during the activation process. This may be observed with a hand-held type digital PH meter. A typical reading is 7.2 at the start of the activation cycle, and a value of 7.1 7.3 at the end. (The electrical energy should be removed when making a measurement.) Of course, if the PH level should shift, as would occur with a non-symmetrical AC waveform, the shift does not necessarily mean that the solution can not be used.
The method of generating the electrical signals is known and consists generally of a power source, a signal generator and a high power amplifier. Biological currents (electron transport functions) operate at very small currents in mammals, on the order of nanoamps and less, and so are easily overloaded at currents as small as about 1 milliamp. This limits the amount of excitation energy that is useable with existing transcutaneous devices. However, if a large amount of power is used on a bio-compatible material, new beneficial properties are obtained.
In order to overcome the power limitation, a medium, functioning as an intermediate transfer solution, is employed. Electrical signals are applied to the medium, which is then applied to the patient after removal of current therethrough. In this way more power may be used than would normally be comfortable or safe for the patient if current were to flow through the patient.
In order to excite the solution adequately enough to become activated, it is necessary to use a relatively large amount of power. The minimum power density required is about 10 milliwatts per milliliter. Thus, if a 100 milliliter (about 4 oz.) batch is prepared, at least 1 watt and preferably 100 watts of power should be used.
If a simple 60 hertz AC line waveform were used, it is not possible to activate the solution. This is because at the high power levels required, the solution exhibits strong electrolysis action at low frequencies and the solution vaporizes away before the solution can become sufficiently active.
In order to allow the solution to absorb high power levels and yet prevent premature electrolysis of the solution, a specific novel technique is employed. This comprises using an electrical signal that preferably comprises an alternating current signal operating in the frequency range of between approximately 10 KHz and approximately 1 MHz, with between approximately 25 KHz and approximately 100 KHz being optimum. When operating at the specified frequency, the gassing away of the solution is reduced by about 100 to 1000 times that of a lower frequency or DC signal. There are also substantially more phase reversals of the current flow per unit of time, and orders of magnitude more current and power may be used. The electron agitation is also increased over lower frequencies.
By switching the polarity of the current on a sufficiently quick periodic basis, the atoms may be partially electrolyzed (separated), yet reco bined back together again before any gas escapes. This partial electrolysis, current phase reversal, then recombining and then re-separating again may be what contribute to the substance becoming electrically activated. At this frequency, the current reverses direction faster than molecules can be atomized, broken up, and escape, and little gassing is released. The new properties that the solution takes on at the specified frequency and power levels then allow it to absorb significantly more energy than at lower frequencies. In fact, the solution can now absorb enough energy to cause electrical conduction heating of the solution. This is the ideal condition for creating the activated substance. The temperature rise of the substance during activation will be approximately at least 3, 4, or 5 degrees and up to approximately 100 degrees Fahrenheit above ambient, depending on the actual power level used.
The frequency used is critical to the success of the device. The substance will not become properly electrically activated if the correct frequency is not used. The frequency range called for is the one that allows the most bio-compatible activation. For example, if a frequency of 60 hertz is used, the substance will electrolyze away in only a few minutes at the power levels called for in this invention. Additionally, the substance will just not generate the biological response that frequencies in the range specified will. At frequencies above about 1 MHz, the present medium will not take on the biological activation qualities, although there may be other mediums which will respond at that frequency. For example, applying microwave frequency energy to water will not result in biologically active activation of the substance. Thus the frequencies specified are found to work best. It is thought the current and frequency range of this invention causes the molecules or atoms to become more fully dissociated and unformed. This means groups of atoms or molecules that normally gather together are broken apart into the smallest possible units. They may also take on a random spin, where electrons are not shared between atoms of a molecule in a familiar and stabilized manner. The bonding levels may also be affected. When partially separated molecules are reformed, the atomic structure may take on slightly different formations in the presence of the applied power. It is thought this random state reforming is what makes the substance active.
Preferably, the alternating current has approximately minimal direct current bias to prevent PH shift and gassing. In order to mitigate direct current bias, the electrical signal is preferably applied to the substance via a capacitor-resistor network. Alternatively, the electrical signal is applied to the substance via an isolation transformer. The electrical signal preferably has a voltage of between approximately 50 volts rms and approximately 150 volts rms. The electrical signal is applied to the substance to be electrically activated via at least one pair of electrodes. A plurality of pairs of electrodes may be utilized, if desired. For optimum results, the electrodes are comprised of an electrically and biologically inert, non-reactive metal or a non-metallic material having a low atomic number and low resistance. For example, gold, carbon, and graphite-carbon material are suitable. It has been found that lead, aluminum, copper, and other metals are not recommended for the practice of this invention, as they can cause lead ions, for example, to leach into the solution, potentially poisoning the patient. Silver provides possible antibiotic, antiseptic properties to the substance, and may optionally be used or added to the substance when this is desirable.
Additionally, multiple pairs of electrodes may be used with various different phase relationships. In this case, it may not be necessary for there to be minimal DC bias at all, as if one pair of electrodes has a positive DC bias, and another pair has a negative DC bias, the net charge bias into the solution may be near zero, thereby effectively eliminating the undesired electrolysis effect.
When distilled water is to be electrically activated, then a substance must often be added to the water to introduce impurities therein, so as to facilitate current flow therethrough. According to one embodiment of the present invention, sodium chloride (salt) or minerals are added to form an electrolyte from distilled water. According to the preferred embodiment of the present invention, the additive substance, e.g., sodium chloride, is added to the distilled water while monitoring current flow therethrough, until the desired current is obtained. This process makes it easier for the operator, and provides more consistent results.
According to a preferred embodiment of the present invention, approximately 1 amp rms of current is caused to flow through the substance to be electrically activated. Typically, a voltage of approximately 100 volts rms is required to effect a current of 1 amp rms. It has been found that currents as low as 1 miiliamp may be used, if desired. Preferably, at least 10 milliwatts of power per milliliter of substance are utilized. When a large amount of power is used in the activation process, new beneficial properties are obtained.
Those skilled in the electrical art will appreciate that the voltage required to effect the desired current is dependent upon the conductivity of the substance being electrically activated. Topical application of the electrically activated substance of the present invention has been found to be effective in mitigating wrinkles on human skin.
Additionally, the substance may be taken orally to obtain additional benefits. When taken orally, approximately 2 ml of the electrically activated substance is preferably ingested per day for approximately 6 weeks.
Furthermore, the substance has also been found to provide useful qualities for the treatment of internal conditions if applied correctly.
These, as well as other advantages of the present invention will be more apparent from the following description and drawings.
Brief Description of the Drawings Figure 1 shows apparatus including a variable frequency current source being utilized to electrically activate a liquid contained within a beaker; Figures 2 and 3 are block diagrams showing alternate configurations of the apparatus of Figure 1; Figure 4 is a flow chart showing the steps involved in the practice of the therapy method, according to the present invention.
Figure 5 illustrates one example of an alternating current waveform at the output of the current source of Figure 1.
Figures 6-8 and 13 illustrate the electrically activated substance being applied to biological tissue. Figures 9, 10, 11 a-c, and 12a-b show tissue changes and results obtained after the electrically activated substance has been applied thereto.
Detailed Description of the Preferred Embodiment The detailed description set forth below in connection with the appended drawings is intended as description of the presently preferred embodiment of the invention and is not intended to represent the only form in which the present invention may be constructed. The description sets forth the functions and the sequence of steps for constructing and operating the invention in connection with the illustrated embodiment. It is to be understood, however, that the same or equivalent functions and sequences may be accomplished by different embodiments that are also intended to be encompassed within the spirit and scope of the invention.
The electrically activated substance and method for making the same of the present invention are illustrated in Figures 1-13 of the drawings which depict presently preferred embodiments thereof.
Referring now to Figure 1, a variable frequency current source 10 is electrically connected, via wires 12, to probes or electrodes 14 which are at least partially immersed within the substance 18 to be electrically activated, which is contained within a beaker 16. Alternatively, a fixed frequency current source may be used.
The variable frequency current source 10 preferably generates an output with a frequency within the range of from approximately 10 KHz to approximately 1 MHz, and a voltage output from approximately 50 volts rms to 150 volts rms, and having a maximum current output in excess of 1 amp rms, and provides preferably a generally symmetrical alternating current waveform. According to the preferred embodiment of the present invention, the variable frequency current source 10 also provides an alternating current output having minimal direct current bias, as illustrated in Figure 5 of the drawings.
In order to re-structure the molecules in the solution within the beaker 16, a high frequency alternating current (AC) signal, preferably having a generally symmetric waveform, is utilized. Thus, for example, referring to Figure 5, a sinusoidal waveform is suitable, as would be a square AC waveform, a triangular AC waveform, or any odd- shaped AC waveform with preferably equal energy in each polarity. A square wave generally provides the highest power and best result. Those skilled in the electrical art will appreciate that various other waveforms, both symmetrical and non-symmetrical, would likewise provide alternating flow of current. Additionally, various other combinations of waveforms may likewise be suitable if they provide a beat or resonance or modulation signal within the 10 Khz to 1 MHz band. According to the preferred embodiment of the present invention, the frequency output of the variable frequency current source 10 is capable of being swept or automatically varied between a minimum and maximum frequency. Alternatively, the variable frequency current source 10 is capable of being manually swept in frequency.
The wires 12 preferably comprise copper wires having a current rating sufficient to carry the required current, e.g., 1 amp rms, without excessive heating.
Typical dimensions for the electrodes 14 are 3 mm thick, 20 mm wide, and 10 cm long. However, as those skilled in the art will appreciate, various different dimensions and cross-sectional configurations, e.g., round, oval, square, triangular, etc., may likewise be suitable.
Preferably, the electrical resistance of the finished electrodes is less than 500 ohms/cm2, preferably less than 50 ohms/cm2.
Further, according to the preferred embodiment of the present invention, the two electrodes are positioned several centimeters apart in a 250 ml container, e.g., the beaker 16. The beaker 16 is preferably formed of a non- conductive material, such as glass or plastic. Thus, as described herein, the method for electrically activating the substance 18 is preferably practiced utilizing approximately 200 ml of the substance at a time. The actual quantity of substance electrically activated may be varied widely by varying the dimensions of the container, electrodes, and by varying the strength of the electrical signal appropriately.
In one embodiment, current flow through the substance 18 being electrically activated is monitored as an electrolytic substance is added thereto so as to form an electrolyte. For example, when water is being electrically activated, then sodium chloride is added to the water, so as to form an electrolyte. As the sodium chloride is added to the water, current flow through the water may be monitored until the desired current flow is achieved, thereby indicating that sufficient sodium chloride has been added to the water.
According to the preferred embodiment of the present invention, approximately 1 amp rms of current is caused to flow through the substance 18 being electrically activated while a voltage of approximately 100 volts rms is applied thereto. Various other voltage and amperage levels are likewise suitable. Typically, current is allowed to flow through the substance being electrically activated for approximately 4-8 hours. At this point there will usually be small gas bubbles formed upon the electrodes. At this point, the substance has been fully electrically activated and is ready to use.
The degree to which the substance 18 is electrically activated, and thus the effectiveness thereof, is directly related to the voltage applied to the electrodes 14, the spacing of the electrodes, the current caused to flow between the electrodes, and, to some extent, the length of time that the current is applied. As indicated in Figure 4, current must flow between the electrodes for a minimum of at least 10 minutes before any usable results are typically obtained. It is thought that the application of current for a time period in excess of 8 hours produces little additional effectiveness of the electrically activated substance. The recommended period of time is 4-12 hours.
The electrically activated substance is typically active for only a limited amount of time after current flow therethrough has ceased. The electrically activated substance is thought to be most effective if utilized within approximately 4 hours after its production. The electrically activated substance is thought to be somewhat effective for up to 4 days after its production, and almost totally diminished after 7 days. It is believed that the decay in the effectiveness of the electrically activated substance is logarithmic in nature, with more than half of the effectiveness thereof lost within approximately 24 hours. Thus it is important to use the substance promptly to derive the benefits described herein.
The specified values for the applied voltage, duration, and conductivity of the medium may be varied somewhat. Indeed, a reduction in the effectiveness of the electrically activated substance may be compensated for by varying one or the other of the production parameters.
For example, a lower voltage may be utilized if additional sodium chloride is added to the solution. However, if too much sodium chloride is added, then the solution may become less bio-compatible. Conversely, if less sodium chloride is utilized, then a higher voltage is necessary to obtain sufficient current flow through the substance.
Inadequate current flow through the substance results in substantially reduced effectiveness of the electrically activated substance.
It is thought that the electrically activated substance of the present invention, when applied to biological tissue, initiates a weak electrical (or ionic) signal in the tissue, similar to the alert signal that occurs when a mechanical strain to the tissue has occurred. This is possibly caused by the spin, valence, or magnetic coupling or polarizing activity of the activated substance. The activated substance may possibly work by loosening weak molecular bonds in the tissue, thereby causing a regeneration response as the bonds or tissues recover. The activity of the substance triggers accelerated metabolic activity in the treatment area. Blood flow accelerates while cellular metabolic activity and interactions increase. As is best shown in Figures 9 and 10, capillaries and/or blood vessels 50 dilate following the treatment and there is increased cellular activity. Toxins, free radicals, metabolic waste and remnant material may be re-formed or flushed away.
The electrically activated substance of the present invention need not be applied to fresh injury sites. It may interfere with the timing and development of the natural current of injury, thereby inhibiting the healing process. However, once the injury has stabilized, the electrically activated substance of the present invention may be applied thereto so as to enhance or re-stimulate the healing process.
One use of the electrically activated substance of the present invention is the treatment of skin sagging.
Preferably, the water is activated with a frequency of between approximately 50 KHz and 100 KHz. When injected for this purpose, there is a uniform reduction of sagging throughout the body. After each application, the recovery phase typically has a duration of approximately 1 to 7 days. After about
4 days, most of such recovery has occurred. At the end of the recovery phase, another treatment may be applied. It has been found that the recovery phase must be complete before a subsequent treatment, so as to avoid overwhelming the response mechanism.
It has been found that approximately three to six such treatment sessions are typically required for maximum results. One session every one to two weeks. The more degenerated the tissue, the more dramatic the results are. The substance also exhibits strong anti-viral properties. The general result is renewed appearance, without surgery, grafting, patchwork, dermabrasion, laser vaporization, or other invasive or mechanical techniques. Additionally, electric current is never caused to pass through living tissue or cells directly.
In addition to being used to treat wrinkles, the substance may also be advantageously used to treat pulmonary conditions. This is shown in Figure 6. The electrically activated substance 18 is inhaled as a mist, or droplet form. This is preferably accomplished with the use of a conventional nebulizer 74 to convert the liquid to a vaporous material 72.
Such nebulizers are commercially available through various health care providers. Some models use compressed air or mechanical vibrations to convert a liquid or fluid to a fine mist. One such device is sold under the trademark "Micro Air" by Omron Industries. This device brakes the liquid into small particles from approximately 1 micron to 10 microns in size. These particles are clumps of molecules. When the substance is converted to a vaporous mist 72 in this manner, the electrically activated properties of the substance are found to remain. When the electrically activated substance 72 is inhaled, additional advantages and benefits to the recipient are realized. For example, when inhaled as a mist, the substance may be used to beneficially treat lung and pulmonary tract problems and disorders.
That is, pulmonary fibrosis, some types of emphysema, and other conditions may be treated in this manner. Interstitial fibrosis occurs when lung tissue becomes scarred and loses its flexibility and elasticity. This can happen after an infection, for example, or contact with an irritant and can make breathing difficult and even painful. There may also be a loss of capillary and blood-gas (air) exchange function. This condition can be improved when the vaporous mist 72 is inhaled.
Figure 12a shows a cutaway patch of pulmonary fibrosis tissue 90. The tissue 90 is largely composed of fibrous strands 91. There are a lack of blood vessels, and the tissue is stiff. Figure 12b shows the same portion of tissue 90 after coming into contact with the vaporous mist 72 of Figure 6. The mist 72 helps to soften and diminish the fibrous tissue 91 and generate new blood vessels 92, thereby helping to restore normal capillary action and lung function.
Emphysema occurs when air sacs (alveoli) in the lungs burst. This is the result of weakened connective tissue. It is often initiated by air pollutants. The active-energy properties of the substance of this invention acts to improve the condition of the connective tissue and dislodge and remove contaminants. In this way further destruction is minimized and even some function restored. Arterial plaque is another condition which is desirous to treat. This is a commonly occurring condition. It is partly influenced by diet. The plaque is largely composed of fats and lipids which have not been metabolized. These fatty deposits become attached to artery walls and surfaces and can build up over a period of time. These same fatty deposits may also build up in other tissues throughout the body. If the buildup continues, the plaque can reduce the size of arterial passageways, thereby inhibiting blood flow and impairing chemical function and activity. The fatty deposits may also accumulate in the body in general. This is shown in Figure 11 a. The cross sectional view of an artery 122 has a build up 121 on the interior lining 123 which constricts its size, reducing the flow of blood therethrough.
The activated substance of the invention, when prepared as described herein, has been found to possess unique capabilities resulting in an effective and useful technique of treating such a plaque condition when the substance is injected into the blood stream. A syringe, catheter, or other such type of device may be used to effect the internal injection. This is shown in Figure 7. A hypodermic needle 71 is attached to a syringe 73 or a container containing the electrically activated substance 18. The needle 71 is inserted through the epidermal layers of skin in order to inject the substance 18. In Figure 8, an I.V. feed may also be used. A hypodermic needle 71 is attached to a tube 75 and a container 77 containing the electrically activated substance 18. The needle 71 is inserted through the epidermal layers of skin in order to inject the liquid 18.
Figure 11b shows the artery 122 of Figure 11a with the activated substance 18 contacting the blood 124 and the plaque 121. Figure 11c shows the same artery 122 with the plaque 121 diminished in size after the treatment.
Figure 13 shows a hypodermic needle 81 connected to a syringe 82 that carries the activated substance to be injected through the skin of an animal.
Graduation marks on the syringe 73 or the IV container 77 measure the amount of activated liquid 18 to be applied in a dose. When injected, the typical dose rate is one to two cc's per 100 pounds of body weight.
When injected in this way, blood flow and metabolic activity accelerates and increases beginning about 15 minutes after the injection. There will begin a flushing action in the tissue. The heart will beat stronger. There may be a very slight fever. There is a slight tingling sensation, but no pain. This will last 1-2 days. After this period of accelerated blood flow, the body enters a recovery phase wherein the cellular structure thereof is rebuilt.
When taken internally as an injection or IV into the blood stream, the molecular action of the electrically activated substance then becomes useful to dissolve, soiubolize, loosen and remove fatty deposits and plaque buildup from the artery walls. This increases capillary and general blood flow and action. When the fatty deposits which commonly occur in the blood vessels and throughout the body and blood flow system are cleaned away and solubolized as described herein, the chemical and metabolic efficiency and effectiveness of the body thereafter increases greatly, causing significant and substantial improvements in the functioning, operation, and regeneration ability of most all body systems and processes. This will then allow the strengthening of arterial walls and improve the production of collagen and ligament type support structures. Thus, the method provides a new, useful and effective treatment for plaque build up conditions and positive additional benefits. The process thus also serves to provide pain relief to the recipient.
There are minimal other outward signs during treatment, however the skin may become temporarily wrinkled. The wrinkling is caused by the skin drawing together on the inside of the body, resulting in bunching up on the outside. This fades away after a while. After the first treatment, and particularly after 3-6 treatments 1 week apart, facial characteristics are smoothed and sagging features become lifted. Other typical uses for the substance when injected are for the treatment of internal organs in general, as well as the blood and circulation system, and other textbook medical/cosmetic conditions, and is applicable to both humans and animals.
When used as an internal injection or IV, the substance is often best administered several times over a period of weeks or months. The first few treatments may be at a lower dosage rate to avoid an excessively strong reaction the first time the product is used.
Although an exemplary technique has been disclosed, there are other acceptable means of injecting the electrically activated substance into the body. It may also be applied with somewhat effectiveness as a douche or applied through the use of various tubes and with other devices without departing from the spirit and scope of the invention.
The substance may also be inhaled or injected along with other materials, nutrients, and drugs, without departing from the scope of this invention.
Because the electrically activated substance of the present invention functions as a transfer agent or medium, there is no current flow from the current source through biological tissue. Thus, there is no chance of bums, thereby enhancing the safety of such treatment. Further, there is no muscle contraction or nerve impulse firing as a result of using the electrically activated substance of the present invention, as is common during contemporary transcutaneous electrotherapy. Furthermore, there is substantially no removal of tissue, unlike dermabrasion and other techniques, and no acid/base effects on the body from PH shifts.
Although several uses have been described, there are of course many other medical conditions in both humans and animals which may respond favorably in this manner. For example, the substance has been found to have strong anti-viral properties, and may be used by itself or with other drugs, as well as for generally treating pain. The substance is also useful in treating and repairing conditions associated with damaged and cross-linked protein structures.
Referring now to Figures 2 and 3, if the variable frequency current source 10 does not provide approximately 0 direct current bias, then the output thereof can be processed so as to mitigate direct current bias.
With particular reference to Figure 2, a resistor-capacitor network 22 may be used to filter the output of the variable frequency current source 10, so as to mitigate direct current bias. Such a resistor-capacitor network comprises at least one capacitor 26 in series with the substance 18 being electrically activated and at least one resistor 28 in parallel therewith. The resistor-capacitor network 22 functions according to known principles to mitigate the presence of DC bias in the substance being electrically charged. Those skilled in the art will appreciate that various other types of filters may be utilized. For example, a capacitor inductor network may be utilized.
With particular reference to Figure 3, an isolation transformer 24 isolates the substance 18 to be electrically charged from direct current bias present in the output of the variable frequency current source 10.
In any instance, when the variable frequency current source 10 does not include a means for monitoring current flow through the substance 18 being electrically activated, then such means is preferably included in the electrical path of the electrodes 14. For example, an amp meter 20 may be inserted in line or applied inductively to one of the wires 12 which provide an electrical pathway for the current which travels between the electrodes 14. Alternatively, an oscilloscope may be utilized to monitor current flow and voltage between the electrodes 14.
Referring now to Figure 4, the method for forming the electrically activated substance 18 of the present invention generally comprises the step 30 of providing distilled water, the step 32 of adding sodium chloride to the distilled water while monitoring current flow between the electrodes 14, the step 34 of applying alternating current to the electrodes 14 and the step 36 of administering the electrically activated substance, preferably within four hours after the electrical activation thereof.
The electrically activated substance is only administered after first discontinuing the application of current thereto. In this manner, the electric current can be applied to an intermediate material (i.e., the electrically activated substance), rather than directly to a person. Thus, a substantial amount of power may be applied to the electrically activated substance, without undesirable interference with biological processes which would occur if an electrical signal of strong energy were applied directly to a recipient. Indeed, according to the preferred embodiment of the present invention, much more power (for example 100 watts), can be applied to the electrically activated substance than could comfortably be tolerated by human tissues.
The minimum amount of power applied to the substance during electrical activation thereof must be sufficient to overcome the activation decay rate of the substance. A small activation energy will disperse as quickly as it is generating, prohibiting adequate activation of the substance. It has been found that the application of at least approximately 10 milliwatts of electrical power, and preferably 100-400 milliwatts, per milliliter of substance results in an acceptable decay rate.
Non-distilled or tap water or other bio-compatible compounds, including tissue products, may be utilized instead of distilled water. It has been found that tap water is frequently suitable for use in the practice of the present invention. However, as those skilled in the art will appreciate, the types and amounts of impurities found in tap water vary considerably from one location to another. Thus, if an accurate analysis of the tap water to be utilized is not available, then the effectiveness and current flow therethrough may be determined by trial and error.
Various other electrolyte-forming substances, other than sodium chloride, are likewise suitable including but not limited to potassium, salts and minerals.
The application of alternating current during step 34 to the substance to be electrically activated preferably takes place for a duration of approximately 4 to 8 hours. After this amount of time, there may be small gas bubbles on the electrodes.
The electrically activated substance is created using the power levels, frequencies, current densities, and dosage quantities described herein. When the substance is produced in this manner, it takes on unique properties.
The electrically activated substance is created using the power levels, frequencies, current densities, and dosage quantities described herein, or parameters comparable to those described herein. When the substance is produced in this manner, it takes on unique properties (possibly on an atomic level), which make it particularly well suited for the practice of the present invention.
It is understood that the exemplary methods described herein and shown in the drawings represent only a presently preferred embodiment of the invention. Indeed, various modifications and additions may be made to such embodiment without departing from the spirit and scope of the invention. For example, various different sizes, shapes and configurations of the container, the electrodes, and the source and type of alternating current are contemplated. Further, the use of water as the electrically activated substance is by way of example only, not by way of limitation. Indeed, it is also anticipated that gases, as well as liquids and conductive solids may be electrically activated according to the techniques of the present invention. Thus, the invention provides a new and useful therapy.
These and other modifications may be adapted to the present invention in keeping with the original spirit and scope of the invention.

Claims

WHAT IS CLAIMED IS:
1. Use of an electrically conductive substance in the preparation of a medicament for localized treatment of an internal body part, said electrically conductive substance being prepared by: placing an electrically conductive substance in a container such that said electrically conductive substance is separated from the body area of the recipient in need of treatment; applying an alternating electric current in the frequency range of between 10 KHz and 1 MHz to said electrically conductive substance for a period of time sufficient to electrically activate said conductive substance; and removing said alternating current.
2. The use as recited in Claim 1, wherein the medicament is in a form suitable to be injected into the body part.
3. The use as recited in Claim 2, wherein the body part is the heart or the vasculature.
4. The use as recited in Claim 2, wherein the medicament is in a form suitable to be injected into the body part with a syringe.
5. The use as recited in Claim 2, wherein the medicament is in a form suitable to be injected into the body part intravenously.
6. The use as recited in Claim 1, wherein the medicament is in a form suitable to be to be inhaled into the pulmonary tract of the recipient.
7. The use as recited in Claim 6, wherein the medicament is a mist.
8. The use as recited in Claim 1 , wherein the medicament is a liquid.
9. The use as recited in Claim 1, wherein said alternating electric current is in the frequency range of between 50 KHz and 100 KHz.
10. The use as recited in Claim 1, wherein said alternating electric current has substantially no direct current bias.
11. The use as recited in Claim 10, wherein the medicament is in a form suitable to be injected into the body part.
12. The use as recited in Claim 11 , wherein the body part is the heart or the vasculature.
13. The use as recited in Claim 11, wherein the medicament is in a form suitable to be injected into the body part with a syringe.
14. The use as recited in Claim 11, wherein the medicament is in a form suitable to be injected into the body part intravenously.
15. The use as recited in Claim 10, wherein the medicament is in a form suitable to be to be inhaled into the pulmonary tract of the recipient.
16. The use as recited in Claim 15, wherein the medicament is a mist.
17. The use as recited in Claim 10, wherein the medicament is a liquid.
18. The use recited in Claim 1, wherein said alternating current is generated from at least one pair of electrodes connected to an alternating current source, and wherein the electrically conductive substance is prepared by the further step of mitigating direct current bias from said alternating current source by attaching a filter network between said current source and said pair of electrodes, said filter network having a capacitor connected in electrical series between said current source and one of said pair of electrodes and a resistor connected in electrical parallel with said capacitor and between said pair of electrodes.
19. The use recited in Claim 1, wherein said alternating current is generated from at least one pair of electrodes connected to an alternating current source, and wherein the electrically conductive substance is prepared by the further step of isolating said electrically conductive substance from a direct current bias of said alternating current source by connecting an isolation transformer between said alternating current source and said pair of electrodes.
20. The use as recited in Claim 1, wherein said alternating electric current is generated by an alternating current source, wherein said alternating current source has an output power of approximately 10 milliwatts per milliliter of said electrically conductive substance.
21. The use recited in Claim 20, wherein said alternating current is generated from at least one pair of electrodes connected to an alternating current source, and wherein the electrically conductive substance is prepared by the further step of mitigating direct current bias from said alternating current source by attaching a filter network between said current source and said pair of electrodes, said filter network having a capacitor connected in electrical series between said current source and one of said pair of electrodes and a resistor connected in electrical parallel with said capacitor and between said pair of electrodes.
22. The use recited in Claim 20, wherein said alternating current is generated from at least one pair of electrodes connected to an alternating current source, and wherein the electrically conductive substance is prepared by the further step of isolating said electrically conductive substance from a direct current bias of said alternating current source by connecting an isolation transformer between said alternating current source and said pair of electrodes.
23. The use as recited in Claim 20, wherein the medicament is in a form suitable to be injected into the body part.
24. The use as recited in Claim 23, wherein the body part is the heart or the vasculature.
25. The use as recited in Claim 23, wherein the medicament is in a form suitable to be injected into the body part with a syringe.
26. The use as recited in Claim 23, wherein the medicament is in a form suitable to be injected into the body part intravenously.
27. The use as recited in Claim 20, wherein the medicament is in a form suitable to be to be inhaled into the pulmonary tract of the recipient.
28. The use as recited in Claim 27, wherein the medicament is a mist.
29. Use of an electrically conductive substance in the preparation of a medicament for treatment of an internal body part, said electrically conductive substance being prepared by: placing an electrically conductive substance in a container such that said electrically conductive substance is separated from the body area of the recipient; locating at least one pair of electrodes within the electrically conductive substance of said container and spacing said pair of electrodes from one another; connecting an alternating current source to said at least one pair of electrodes and operating said current source to generate alternating current having a frequency lying in a range of frequencies between 10 KHz and 1 MHz so that current flows through said electrically conductive substance and between said electrodes for at least 10 minutes; removing said alternating current flow through said electrically conductive substance after said at least said 10 minutes, and; following removal of said electrical current through said electrically conductive substance, injecting said electrically prepared substance internally into the body of the recipient within 7 days.
30. The method as recited in Claim 29, wherein said alternating current applied from said alternating current source to said electrically conductive substance has substantially no direct current bias.
31. The method as recited in Claim 29, wherein the electrically conductive substance to be applied internally is injected into the body of the recipient for the purposes of treating heart or circulatory conditions of the recipient.
32. The method as recited in Claim 29, wherein the electrically conductive substance is injected into the recipient with a syringe.
33. The method as recited in Claim 29, wherein the electrically conductive substance is injected into the recipient with a hypodermic needle.
34. The method as recited in Claim 29, wherein the substance contains water to which an electrolytic material has been added.
35. The method as recited in Claim 29, wherein the electrically conductive substance is injected internally for purposes of treating internal organs of the recipient.
36. Using electrically conductive substance in the preparation of a medicament for treatment of an internal body part, said electrically conductive substance being prepared by: placing an electrically conductive substance in a container such that the said electrically conductive substance is separated from the body area of the recipient; locating at least one pair of electrodes within the electrically conductive substance of said container and spacing said pair of electrodes from one another; connecting an alternating current source to said at least one pair of electrodes and operating said current source to generate alternating current having a frequency lying in a range of frequencies between 10 KHz and 1 MHz so that current flows through said electrically conductive substance and between said electrodes for at least 10 minutes;
IB- removing said alternating current flow through said electrically conductive substance after said at least said 10 minutes, and; following removal of said electrical current through said electrically conductive substance, inhaling said electrically prepared substance internally into the pulmonary tract of the recipient within 7 days.
37. The method as recited in Claim 36, wherein the electrically conductive substance inhaled into the pulmonary tract of the recipient in small droplet mist form.
38. The method as recited in Claim 29, wherein the recipient is an animal.
39. The method as recited in Claim 36, wherein the recipient is an animal.
40. The method as recited in Claim 29, wherein the recipient is an animal and the substance is injected into the body of the animal with a hypodermic needle.
41. The method as recited in Claim 29 wherein sufficient power is used when activating the substance to raise the temperature of the substance by at least 4 degrees Centigrade.
42. The method as recited in Claim 29, where the operating frequency of said alternating current source used to generate said alternating current is composed of frequencies that lie in a range of frequencies between 50KHz and 100KHz.
43. The method recited in Claim 29, including the additional step of mitigating direct current bias from said alternating current source to said electrically conductive substance by attaching a filter network between said current source and said pair of electrodes, said filter network having a capacitor connected in electrical series between said current source and one of said pair of electrodes and a resistor connected in electrical parallel with said capacitor and between said pair of electrodes.
44. The method recited in Claim 29, including the additional step of isolating said electrically conductive substance from direct current bias of said alternating current source by connecting an isolation transformer between said alternating current source and said pair of electrodes.
45. Use of an electrically conductive substance in the preparation of a medicament for treatment of an internal body part, said electrically conductive substance being prepared by: placing an electrically conductive substance in a container such that said electrically conductive substance is separated from the body area of the recipient in need of treatment; locating at least one pair of electrodes within the electrically conductive substance of said container and spacing said pair of electrodes from one another; connecting an alternating current source to said at least one pair of electrodes and operating said current source to generate alternating current having substantially no direct current bias and a frequency lying in a range of frequencies between 10 KHz and 1 MHz, wherein the output power of said alternating current source is approximately 10 milliwatts per milliliter of said electrically conductive fluid in said container, so that current flows through said electrically conductive substance and between said pair of electrodes for at least 10 minutes; removing said alternating current flow through said electrically conductive substance after said at least 10 minutes, and; following removal of said electrical current through said electrically conductive substance, injecting said electrically prepared substance internally into the body of the recipient within 7 days.
46. The method as recited in Claim 45, wherein the electrically conductive substance to be applied internally is injected into the body of the recipient, for the purposes of treating heart and circulatory conditions of the recipient.
47. The method as recited in Claim 45, wherein the prepared electrically conductive substance is injected into the body of the recipient with a syringe.
48. The method as recited in Claim 45, wherein the electrically conductive substance is injected into the body of the recipient with a hypodermic needle.
49. The method as recited in Claim 45, wherein the recipient is an animal.
50. The method as recited in Claim 45, wherein the recipient is an animal and the substance is injected into the animal with a hypodermic needle.
51. The method as recited in Claim 45, wherein the substance contains water to which an electrolytic material has been added.
52. Use of an electrically conductive substance in the preparation of a medicament for treatment of an internal body part, said electrically conductive substance being prepared by: placing an electrically conductive substance in a container such that said electrically conductive substance is separated from the body area of the recipient in need of treatment; locating at least one pair of electrodes within the electrically conductive substance of said container and spacing said pair of electrodes from one another; connecting an alternating current source to said at least one pair of electrodes and operating said current source to generate alternating current having substantially no direct current bias and a frequency lying in a range of frequencies between 10 KHz and 1 MHz, wherein the output power of said alternating current source is approximately 10 milliwatts per milliliter of said electrically conductive fluid in said container, so that current flows through said electrically conductive substance and between said pair of electrodes for at least 10 minutes; removing said alternating current flow through the said electrically conductive substance after said at least 10 minutes, and; following removal of said electrical current through said electrically conductive substance, inhaling said electrically prepared substance as a mist into the pulmonary tract of the recipient within 7 days.
53. The method recited in claim 45, including the additional step of mitigating direct current bias from said alternating current source to said electrically conductive substance by attaching a filter network between said alternating current source and said pair of electrodes, said filter network having a capacitor connected in electrical series between said current source and one of said pair of electrodes and a resistive element connected in electrical parallel with said capacitor and between said pair of electrodes.
54. The method recited in claim 45, including the additional step of isolating said electrically conductive substance from direct current bias of said alternating current source by connecting an isolation transformer between said alternating current source and said pair of electrodes.
55. A method for preparing and using a substance, for use on a body area of a recipient, said method including the steps of: placing an electrically conductive substance in a container such that said electrically conductive substance is separated from the body area of a recipient; locating at least one pair of electrodes within the electrically conductive substance of said container and spacing said pair of electrodes from one another; connecting an alternating current source to said at least one pair of electrodes and operating said current source to generate alternating current having substantially no direct current bias and a frequency lying in a range of frequencies between 50 KHz and 100 KHz, wherein the output power of said alternating current source is at least approximately 10 milliwatts per milliliter of said electrically conductive fluid in said container, so that current flows through said electrically conductive substance and between said pair of electrodes for at least 10 minutes; removing said alternating current flow through said electrically conductive substance after said at least 10 minutes, and; injecting said electrically conductive substance internally to the recipient within 4 days of removing the alternating current flow therethrough.
56. The method as recited in claim 55, wherein the electrically conductive substance to be applied internally is injected into the body of the recipient.
57. The method as desribed in claim 55, wherein the substance is injected into the recipient with a hypodermic needle.
58. The method as described in claim 55 wherein the recipient is an animal.
59. The method as recited in claim 55, wherein the recipient is an animal and the substance is injected with a hypodermic needle.
60. The method as recited in claim 55, wherein the substance contains water to which an electrolytic material has been added.
61. Use of an electrically conductive substance in the preparation of a medicament for treatment of an internal body part, said electrically conductive substance being prepared by: placing an electrically conductive substance in a container such that the said electrically conductive substance is separated from the body area of the recipient; applying an alternating electric current having a frequency lying in a range of frequencies between 10 KHz and 1 MHz to said electrically conductive substance and between said electrodes for at least 10 minutes; removing said alternating current flow from said electrically conductive substance after said at least said 10 minutes, and; following removal of said electrical current application through said electrically conductive substance, injecting said electrically prepared substance internally into the body of the recipient within 7 days.
PCT/US1999/028749 1999-04-09 1999-12-02 Method of providing cosmetic/medical therapy WO2000061221A1 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
UA2001042681A UA78672C2 (en) 1999-04-09 1999-02-12 Method for preparation and use of conductive medicinal substance (variants)
NZ511238A NZ511238A (en) 1999-04-09 1999-12-02 Method of providing cosmetic/medical therapy
BR9914945-1A BR9914945A (en) 1999-04-09 1999-12-02 Process for providing medical / medicinal therapy
JP2000610552A JP2002541222A (en) 1999-04-09 1999-12-02 How to perform cosmetic surgery / treatment
KR1020017012854A KR100670096B1 (en) 1999-04-09 1999-12-02 Electrically activated substance for Internal medicament
CA002356128A CA2356128A1 (en) 1999-04-09 1999-12-02 Method of providing cosmetic/medical therapy
IL14258199A IL142581A0 (en) 1999-04-09 1999-12-02 Method of providing cosmetic/medical therapy
EP99965120A EP1169082A1 (en) 1999-04-09 1999-12-02 Method of providing cosmetic/medical therapy
AU31103/00A AU777730B2 (en) 1999-04-09 1999-12-02 Method of providing cosmetic/medical therapy
PL350850A PL198794B1 (en) 1999-04-09 1999-12-02 Method of providing cosmetic/medical therapy
IL142581A IL142581A (en) 1999-04-09 2001-04-13 Medicament for treating heart disease
NO20014812A NO20014812L (en) 1999-04-09 2001-10-03 Method of Providing Cosmetic / Medical Therapy
HK02105023.8A HK1043326A1 (en) 1999-04-09 2002-07-04 Method of providing cosmetic/medical therapy
HK02105111.1A HK1045270A1 (en) 1999-04-09 2002-07-09 Method of providing cosmetic/medical therapy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/289,409 US6488032B1 (en) 1997-05-29 1999-04-09 Method of providing cosmetic/medical therapy
US09/289,409 1999-04-09

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WO2000061221A1 true WO2000061221A1 (en) 2000-10-19

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EP (1) EP1169082A1 (en)
JP (1) JP2002541222A (en)
KR (1) KR100670096B1 (en)
CN (1) CN1209172C (en)
AU (1) AU777730B2 (en)
BR (1) BR9914945A (en)
CA (1) CA2356128A1 (en)
HK (2) HK1043326A1 (en)
IL (2) IL142581A0 (en)
NO (1) NO20014812L (en)
NZ (1) NZ511238A (en)
PL (1) PL198794B1 (en)
RU (1) RU2244573C2 (en)
TR (1) TR200102816T2 (en)
UA (1) UA78672C2 (en)
WO (1) WO2000061221A1 (en)

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NO20014812D0 (en) 2001-10-03
HK1045270A1 (en) 2002-11-22
NZ511238A (en) 2003-12-19
KR100670096B1 (en) 2007-01-17
KR20010113783A (en) 2001-12-28
TR200102816T2 (en) 2002-06-21
CN1209172C (en) 2005-07-06
IL142581A (en) 2010-12-30
HK1043326A1 (en) 2002-09-13
CA2356128A1 (en) 2000-10-19
PL198794B1 (en) 2008-07-31
RU2244573C2 (en) 2005-01-20
US6488032B1 (en) 2002-12-03
NO20014812L (en) 2001-10-03
UA78672C2 (en) 2007-04-25
AU3110300A (en) 2000-11-14
IL142581A0 (en) 2002-03-10
JP2002541222A (en) 2002-12-03
PL350850A1 (en) 2003-02-10
BR9914945A (en) 2001-10-30
AU777730B2 (en) 2004-10-28
EP1169082A1 (en) 2002-01-09

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