WO2005107928A3 - Metabolic detoxification system and method - Google Patents

Metabolic detoxification system and method Download PDF

Info

Publication number
WO2005107928A3
WO2005107928A3 PCT/US2005/006003 US2005006003W WO2005107928A3 WO 2005107928 A3 WO2005107928 A3 WO 2005107928A3 US 2005006003 W US2005006003 W US 2005006003W WO 2005107928 A3 WO2005107928 A3 WO 2005107928A3
Authority
WO
WIPO (PCT)
Prior art keywords
ultrafiltrate
cellular components
detoxification system
recirculation circuit
active cells
Prior art date
Application number
PCT/US2005/006003
Other languages
French (fr)
Other versions
WO2005107928A2 (en
WO2005107928A9 (en
Inventor
Dar He
John D Brotherton
Original Assignee
Vital Therapies Inc
Dar He
John D Brotherton
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to KR1020067024679A priority Critical patent/KR101278429B1/en
Application filed by Vital Therapies Inc, Dar He, John D Brotherton filed Critical Vital Therapies Inc
Priority to EP05714053.5A priority patent/EP1747056B1/en
Priority to AU2005240515A priority patent/AU2005240515B2/en
Priority to NZ550826A priority patent/NZ550826A/en
Priority to CA2564859A priority patent/CA2564859C/en
Priority to JP2007510723A priority patent/JP5106102B2/en
Priority to BRPI0510369-0A priority patent/BRPI0510369B1/en
Priority to MXPA06012472A priority patent/MXPA06012472A/en
Publication of WO2005107928A2 publication Critical patent/WO2005107928A2/en
Publication of WO2005107928A3 publication Critical patent/WO2005107928A3/en
Priority to IL178898A priority patent/IL178898A/en
Priority to ZA2006/09456A priority patent/ZA200609456B/en
Publication of WO2005107928A9 publication Critical patent/WO2005107928A9/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A61M1/3475—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate with filtrate treatment agent in the same enclosure as the membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A61M1/3486—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
    • A61M1/3489—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents by biological cells, e.g. bioreactor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/38—Removing constituents from donor blood and storing or returning remainder to body, e.g. for transfusion
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/20—Accessories; Auxiliary operations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1694—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes with recirculating dialysing liquid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1698—Blood oxygenators with or without heat-exchangers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3623—Means for actively controlling temperature of blood

Abstract

An extracorporeal filtration and detoxification system and method generally comprise separating ultrafiltrate from cellular components of blood, treating the ultrafiltrate independently of the cellular components in a recirculation circuit, recombining treated ultrafiltrate and the cellular components, and returning whole blood to the patient. A recirculation circuit generally comprises an active cartridge including active cells operative to effectuate a selected treatment; in some embodiments, the active cells are the C3A cell line.
PCT/US2005/006003 2004-04-27 2005-02-23 Metabolic detoxification system and method WO2005107928A2 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
JP2007510723A JP5106102B2 (en) 2004-04-27 2005-02-23 Metabolic detoxification system and method
EP05714053.5A EP1747056B1 (en) 2004-04-27 2005-02-23 Metabolic detoxification system
AU2005240515A AU2005240515B2 (en) 2004-04-27 2005-02-23 Metabolic detoxification system and method
NZ550826A NZ550826A (en) 2004-04-27 2005-02-23 Metabolic detoxification system and method
CA2564859A CA2564859C (en) 2004-04-27 2005-02-23 Metabolic detoxification system and method
KR1020067024679A KR101278429B1 (en) 2004-04-27 2005-02-23 Metabolic detoxification system and method
BRPI0510369-0A BRPI0510369B1 (en) 2004-04-27 2005-02-23 Metabolic detoxification system
MXPA06012472A MXPA06012472A (en) 2004-04-27 2005-02-23 Metabolic detoxification system and method.
IL178898A IL178898A (en) 2004-04-27 2006-10-26 Metabolic detoxification system and method
ZA2006/09456A ZA200609456B (en) 2004-04-27 2006-11-14 Metabolic detoxification system and method

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56588804P 2004-04-27 2004-04-27
US60/565,888 2004-04-27

Publications (3)

Publication Number Publication Date
WO2005107928A2 WO2005107928A2 (en) 2005-11-17
WO2005107928A3 true WO2005107928A3 (en) 2006-09-08
WO2005107928A9 WO2005107928A9 (en) 2010-02-25

Family

ID=35320752

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/006003 WO2005107928A2 (en) 2004-04-27 2005-02-23 Metabolic detoxification system and method

Country Status (14)

Country Link
US (2) US8105491B2 (en)
EP (2) EP3326669A1 (en)
JP (1) JP5106102B2 (en)
KR (1) KR101278429B1 (en)
CN (2) CN101005871A (en)
AU (1) AU2005240515B2 (en)
BR (1) BRPI0510369B1 (en)
CA (1) CA2564859C (en)
IL (1) IL178898A (en)
MX (1) MXPA06012472A (en)
NZ (1) NZ550826A (en)
TW (1) TWI302103B (en)
WO (1) WO2005107928A2 (en)
ZA (1) ZA200609456B (en)

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MXPA06012472A (en) * 2004-04-27 2007-01-26 Vital Therapies Inc Metabolic detoxification system and method.
EP2578081B1 (en) 2006-10-11 2016-03-09 The General Hospital Corporation Compositions, methods, and devices for treating liver disease
EP2091591B1 (en) * 2006-10-30 2014-02-26 Gambro Lundia AB Medical fluid circuit unit
ITMI20070913A1 (en) * 2007-05-07 2008-11-08 Antonio Pesenti BLOOD TREATMENT METHOD TO ELIMINATE AT LEAST PARTIALLY THE CONTENT OF CARBON DIOXIDE AND ITS DEVICE.
EP2002855B1 (en) * 2007-06-14 2012-07-11 RenApta B.V. Artificial kidney
US8034235B2 (en) 2008-02-14 2011-10-11 Baxter International Inc. Dialysis system including supplemental power source
DE102008015387B4 (en) * 2008-03-20 2019-01-10 Sartorius Stedim Biotech Gmbh Pre-sterilizable filtration system for single use
US8512326B2 (en) 2011-06-24 2013-08-20 Arqos Surgical, Inc. Tissue extraction devices and methods
WO2012178119A2 (en) 2011-06-24 2012-12-27 Arqos Surgical, Inc. Tissue extraction devices and methods
US9233193B2 (en) 2011-06-29 2016-01-12 Iogyn, Inc. Surgical fluid management systems and methods
US9737362B2 (en) 2011-07-06 2017-08-22 Boston Scientific Scimed, Inc. Tissue cutting systems and methods
US9084847B2 (en) * 2011-09-22 2015-07-21 Iogyn, Inc. Surgical fluid management systems and methods
US9597149B2 (en) 2011-11-04 2017-03-21 Iogyn, Inc. Tissue extraction devices and methods
US9498244B2 (en) 2012-10-19 2016-11-22 Iogyn, Inc. Medical systems and methods
US9414752B2 (en) 2012-11-09 2016-08-16 Elwha Llc Embolism deflector
CN105377159B (en) 2013-04-08 2018-06-12 波士顿科学医学有限公司 medical system and method
US9486233B2 (en) 2013-04-26 2016-11-08 Iogyn, Inc. Tissue resecting systems and methods
US9943639B2 (en) 2013-10-28 2018-04-17 Boston Scientific Scimed, Inc. Fluid management system and methods
MY184230A (en) * 2013-12-27 2021-03-29 Eliaz Therapeutics Inc Plasmapheresis device
US10178864B2 (en) * 2014-03-08 2019-01-15 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Portable organ perfusion system
WO2016183231A1 (en) 2015-05-12 2016-11-17 Baker Group, LLP Method and system for a bioartificial organ
WO2016205215A1 (en) * 2015-06-15 2016-12-22 Vital Therapies, Inc. Composition and method for inducing anti-inflammatory response
KR20180022721A (en) * 2015-06-15 2018-03-06 바이탈 쎄러피스, 인코포레이티드 Systems and methods for extracorporeal blood treatment
CA2999121C (en) * 2015-09-18 2020-04-14 Eric A. WASHINGTON Urinary collection system and procedure for decreasing catheter-associated bacteriuria
DE102016117725A1 (en) 2016-09-20 2018-03-22 Fresenius Medical Care Deutschland Gmbh A method for removing blood from an extracorporeal blood circulation after completion of a blood treatment session, control and regulation device and treatment device for performing the same
WO2018081524A1 (en) * 2016-10-28 2018-05-03 Vital Therapies, Inc. Use of conditioned media from extracorporeal blood detoxifying system to supplement organ perfusion solutions
DE102017210134A1 (en) * 2016-12-15 2018-06-21 Fresenius Medical Care Deutschland Gmbh Extracorporeal blood treatment system, treatment device, kit and method for operating an extracorporeal blood treatment system
WO2019046304A1 (en) 2017-08-28 2019-03-07 Matthias Wagner Microfluidic laser-activated intracellular delivery systems and methods
CN108211032B (en) * 2018-02-01 2023-11-17 南方医科大学珠江医院 Combined bioartificial liver support system
US11883626B2 (en) 2019-06-27 2024-01-30 Boston Scientific Scimed, Inc. Detection of an endoscope to a fluid management system
CN112755288B (en) * 2020-12-21 2022-06-14 山东壹瑞特生物科技有限公司 In-vitro liver support system
CN113016778A (en) * 2021-02-08 2021-06-25 广东乾晖生物科技有限公司 Isolated organ perfusion preservation system based on mesenchymal stem cells
JP2024510169A (en) 2021-03-07 2024-03-06 セリノ バイオテック，インク． Platforms and systems for automated cell culture
US11931737B2 (en) 2021-09-02 2024-03-19 Cellino Biotech, Inc. Platforms and systems for automated cell culture
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Also Published As

Publication number Publication date
ZA200609456B (en) 2008-04-30
CA2564859C (en) 2013-04-09
IL178898A0 (en) 2007-03-08
IL178898A (en) 2010-11-30
NZ550826A (en) 2011-09-30
MXPA06012472A (en) 2007-01-26
US8608953B2 (en) 2013-12-17
CA2564859A1 (en) 2005-11-17
CN103505766A (en) 2014-01-15
EP1747056A2 (en) 2007-01-31
WO2005107928A2 (en) 2005-11-17
BRPI0510369B1 (en) 2018-05-02
EP3326669A1 (en) 2018-05-30
KR20070012514A (en) 2007-01-25
EP1747056A4 (en) 2012-09-05
BRPI0510369A (en) 2007-11-06
JP2007534440A (en) 2007-11-29
US20050236329A1 (en) 2005-10-27
JP5106102B2 (en) 2012-12-26
AU2005240515A1 (en) 2005-11-17
US20120197174A1 (en) 2012-08-02
WO2005107928A9 (en) 2010-02-25
CN101005871A (en) 2007-07-25
TWI302103B (en) 2008-10-21
TW200538172A (en) 2005-12-01
US8105491B2 (en) 2012-01-31
AU2005240515B2 (en) 2010-09-23
KR101278429B1 (en) 2013-06-24
EP1747056B1 (en) 2018-09-26

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