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Ectopic ATP synthase stimulates the secretion of extracellular vesicles in cancer cells | Communications Biology

Nature
Ectopic ATP synthase on the plasma membrane (eATP synthase) has been found in various cancer types and is a potential target for cancer...
17 months ago

Changes within the central stalk of E. coli F1Fo ATP synthase observed after addition of ATP | Communications Biology

Nature
F1Fo ATP synthase functions as a biological generator and makes a major contribution to cellular energy production.
22 months ago

Spatial and temporal dynamics of ATP synthase from mitochondria toward the cell surface | Communications Biology

Nature
Ectopic ATP synthase complex (eATP synthase), located on cancer cell surface, has been reported to possess catalytic activity that...
19 months ago

ATP-binding and hydrolysis of human NLRP3

Nature
The innate immune system uses inflammasomal proteins to recognize danger signals and fight invading pathogens. NLRP3, a multidomain protein...
25 months ago

IF1 promotes oligomeric assemblies of sluggish ATP synthase and outlines the heterogeneity of the mitochondrial membrane potential | Communications Biology

Nature
The coexistence of two pools of ATP synthase in mitochondria has been largely neglected despite in vitro indications for the existence of...
15 months ago

Cryo-EM structure of the entire mammalian F-type ATP synthase

Nature
The majority of adenosine triphosphate (ATP) powering cellular processes in eukaryotes is produced by the mitochondrial F1Fo ATP synthase.
50 months ago

ATP and nucleic acids competitively modulate LLPS of the SARS-CoV2 nucleocapsid protein | Communications Biology

Nature
Our study deciphers that the essential binding of N protein with nucleic acid and its LLPS are targetable by small molecules including ATP.
22 months ago

A wrench in the motor

Nature
Structural biology and resistance analyses reveal the binding mode and the basis for selective inhibition of the ATP synthase rotary motor protein by...
36 months ago

Asymmetric drug binding in an ATP-loaded inward-facing state of an ABC transporter

Nature
Our findings support a mechanistic role for symmetry mismatch between the nucleotide binding and the transmembrane domains in the conformational cycle of ABC...
35 months ago

Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor

Nature
Cell growth is regulated by the mammalian/mechanistic target of rapamycin complex 1 (mTORC1), which functions both as a nutrient sensor and...
15 months ago