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New Molecular Sensor Tracks Energy Use at the Subcellular Level

WCM Newsroom
ATP sensor targeted to mitochondria in primary neurons. Green indicates the presence of ATP, while red independently labels the sensor.
6 months ago

Conformational ensemble of yeast ATP synthase at low pH reveals unique intermediates and plasticity in F

Nature
Mitochondrial adenosine triphosphate (ATP) synthase uses the proton gradient across the inner mitochondrial membrane to synthesize ATP.
10 months ago

Extracellular ATP/adenosine dynamics in the brain and its role in health and disease

Frontiers
Extracellular ATP and adenosine are neuromodulators that regulate numerous neuronal functions in the brain. Neuronal activity and brain insults such as...
5 months ago

Seminal Study Sheds Light on Cell Mitochondria

SBU News
A promising study toward a better understanding of mitochondrial adenosine triphosphate (ATP) synthase.
9 months ago

Life’s energy currency ATP made using electricity from the grid for the first time

Chemistry World
The gap between manmade electricity and the biochemical energy that powers life, adenosine triphosphate (ATP), has been directly bridged using a new to nature...
14 months ago

ATP synthase — a marvellous rotary engine of the cell

Nature
ATP synthase can be thought of as a complex of two motors — the ATP-driven F1 motor and the proton-driven Fo motor — that rotate in opposite...
279 months ago

Ectopic ATP synthase stimulates the secretion of extracellular vesicles in cancer cells | Communications Biology

Nature
Ectopic ATP synthase on the plasma membrane (eATP synthase) has been found in various cancer types and is a potential target for cancer...
17 months ago

Proton-powered subunit rotation in single membrane-bound F

Nature
Synthesis of ATP from ADP and phosphate, catalyzed by F0F1-ATP synthases, is the most abundant physiological reaction in almost any cell.
250 months ago

Changes within the central stalk of E. coli F1Fo ATP synthase observed after addition of ATP | Communications Biology

Nature
F1Fo ATP synthase functions as a biological generator and makes a major contribution to cellular energy production.
22 months ago

Structure-guided simulations illuminate the mechanism of ATP transport through VDAC1

Nature
The voltage-dependent anion channel (VDAC) mediates the flow of metabolites and ions across the outer mitochondrial membrane of all...
125 months ago